Protective effects of glucocorticoids on ischemia-reperfusion injury of outer hair cells

被引：29
|
作者：
Tabuchi, K [1 ]
Oikawa, K [1 ]
Murashita, H [1 ]
Hoshino, T [1 ]
Tsuji, S [1 ]
机构：
[1] Univ Tsukuba, Dept Otolaryngol, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan
来源：
LARYNGOSCOPE | 2006年 / 116卷 / 04期
关键词：
glucocorticoid; ischemia; outer hair cells;
D O I：
10.1097/01.mlg.0000200963.69342.d7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: This animal study aimed to investigate effects of glucocorticoids on the functional recovery of outer hair cells (OHCs) after transient ischemia. Methods: Distortion-product otoacoustic emission (DPOAE) was examined before, during, and after transient cochlear ischemia of 30 minutes using albino guinea pigs. Results: DPOAE decreased to noise level during ischemia. On recirculation, DPOAE initially recovered with time until 20 minutes after the onset of reperfusion, but thereafter; the DPOAE level gradually decreased toward the noise level in the control animals. Prednisolone and methylprednisolone significantly improved the DPOAE level 60 minutes after the onset of reperfusion. Conclusions: The present findings suggest that glucocorticoids possess protective effects against ischemia-reperfusion injury of OHCs.
引用
收藏
页码：627 / 629
页数：3
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