Synthesis and Cytotoxic Evaluation of 2-O-alkyl Derivatives of L-Ascorbic Acid

被引：0
|
作者：
Dengale, Rohit A. [1 ]
Thopate, Shankar R. [1 ]
机构：
[1] Ahmednagar Coll, Dept Chem, Ahmednagar, Maharashtra, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 04期
关键词：
Alkylation; L-Ascorbic acid derivatives; Cytotoxicity; Desilylation; One-pot synthesis; Silylation; LIPID-PEROXIDATION; INHIBITORS; CELLS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of both 5,6-O-protected and unprotected 2-O-alkyl derivatives of l-ascorbic acid were synthesized using silylation-alkylation-desilylation sequence in a one-pot manner. These derivatives were screened for their anticancer activity against human breast cancer cell line (MCF-7) and exhibited decent cytotoxicity.
引用
收藏
页码：395 / 399
页数：5
相关论文
共 50 条
  • [1] Synthesis and cytotoxic evaluation of novel 2,3-di-O-alkyl derivatives of L-ascorbic acid
    Kote, Santosh R.
    Mishra, Ratnakar
    Khan, Ayesha A.
    Thopate, Shankar R.
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (03) : 1257 - 1266
  • [2] Synthesis and cytotoxic evaluation of novel 2,3-di-O-alkyl derivatives of l-ascorbic acid
    Santosh R. Kote
    Ratnakar Mishra
    Ayesha A. Khan
    Shankar R. Thopate
    [J]. Medicinal Chemistry Research, 2014, 23 : 1257 - 1266
  • [3] Synthesis and Cytotoxic Evaluation of Novel 3-O and 2, 3-Di-O-alkyl Derivatives of L-Ascorbic Acid
    Deshmukh, Santosh Rangnath
    Thopate, Shankar Ramchandra
    [J]. LETTERS IN ORGANIC CHEMISTRY, 2018, 15 (09) : 766 - 772
  • [4] Synthesis of l-Ascorbic Acid Lactone Derivatives
    Shao L.-D.
    Wu Y.-N.
    Xu J.
    He J.
    Zhao Y.
    Peng L.-Y.
    Li Y.
    Yang Y.-R.
    Xia C.-F.
    Zhao Q.-S.
    [J]. Natural Products and Bioprospecting, 2014, 4 (3) : 181 - 188
  • [5] Novel pyrimidine and purine derivatives of L-ascorbic acid: Synthesis and biological evaluation
    Raic-Malic, S
    Hergold-Brundic, A
    Nagl, A
    Grdisa, M
    Pavelic, K
    De Clercq, E
    Mintas, M
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (14) : 2673 - 2678
  • [6] STUDIES ON L-ASCORBIC ACID DERIVATIVES .3. BIS(L-ASCORBIC ACID-3,3') PHOSPHATE AND L-ASCORBIC ACID 2-PHOSPHATE
    NOMURA, H
    ISHIGURO, T
    MORIMOTO, S
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1969, 17 (02) : 387 - +
  • [7] L-ASCORBIC ACID DERIVATIVES .6. PHOSPHORYLATION OF L-ASCORBIC ACID AND ITS ISOPROPYLIDENE DERIVATIVE
    NOMURA, H
    SHIMOMUR.M
    MORIMOTO, S
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1971, 19 (07) : 1433 - +
  • [8] Synthesis, structural studies, and cytostatic evaluation of 5,6-di-O-modified L-ascorbic acid derivatives
    Gazivoda, T
    Wittine, K
    Lovric, I
    Makuc, D
    Plavec, J
    Cetina, M
    Mrvos-Sermek, D
    Suman, L
    Kralj, M
    Pavelic, K
    Mintas, M
    Raic-Malic, S
    [J]. CARBOHYDRATE RESEARCH, 2006, 341 (04) : 433 - 442
  • [9] STUDIES ON L-ASCORBIC ACID DERIVATIVES .2. L-ASCORBIC ACID 3-PHOSPHATE AND 3-PYROPHOSPHATE
    NOMURA, H
    ISHIGURO, T
    MORIMOTO, S
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1969, 17 (02) : 381 - +
  • [10] Synthesis of L-ascorbic acid in the phloem
    Robert D Hancock
    Diane McRae
    Sophie Haupt
    Roberto Viola
    [J]. BMC Plant Biology, 3 (1)
12345