Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space. (C) 2008 Elsevier Ltd. All rights reserved.
机构:
Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R ChinaJinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China
Tang Zhengle
Xing Feiyue
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Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R ChinaJinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China
Xing Feiyue
Chen Di
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Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R ChinaJinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China
Chen Di
Yu Yu
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Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Immunol, Tampa, FL 33612 USA
Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL 33612 USAJinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China
Yu Yu
Yu Chunyan
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Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R ChinaJinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China
Yu Chunyan
Di Jingfang
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Jinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R ChinaJinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China
Di Jingfang
Liu Jing
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Jinan Univ, Dept Stomatol, Guangzhou 510632, Guangdong, Peoples R ChinaJinan Univ, Coll Life Sci & Technol, Inst Tissue Transplantat & Immunol, Guangzhou 510632, Guangdong, Peoples R China
机构:
Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Aksenova, M. S.
Bocharova, E. N.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Bocharova, E. N.
Abbasova, S. G.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Abbasova, S. G.
Ponomarev, A. S.
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Minist Def Russian Federat, Cent Res Inst 48, Sergiev Posad-6 Terr, Sergiev Posad 141306, Moscow Oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Ponomarev, A. S.
Loginova, V. V.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Loginova, V. V.
Bolotnikova, M. V.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Bolotnikova, M. V.
Belskaya, N. V.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Belskaya, N. V.
Kazarov, A. A.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Kazarov, A. A.
Lisova, A. E.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Lisova, A. E.
Kudina, N. K.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Kudina, N. K.
Pantyushenko, M. S.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Pantyushenko, M. S.
Zhilyaeva, M. V.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Zhilyaeva, M. V.
Kopein, D. S.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Kopein, D. S.
Karelov, Yu. M.
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Minist Def Russian Federat, Cent Res Inst 48, Sergiev Posad-6 Terr, Sergiev Posad 141306, Moscow Oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Karelov, Yu. M.
Erastov, G. G.
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Minist Def Russian Federat, Cent Res Inst 48, Sergiev Posad-6 Terr, Sergiev Posad 141306, Moscow Oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Erastov, G. G.
Lykov, M. V.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia
Lykov, M. V.
Khamitov, R. A.
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Joint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, RussiaJoint Stock Co GENERIUM JSC GENERIUM, Vladimir City 601125, Vladimir oblast, Russia