Synthesis and antitumor evaluation of some novel pyrrolizine derivatives

被引：9
|
作者：
Hanna, Mona M. [2 ]
Abdelgawad, Nagwa M. [2 ]
Ibrahim, Nashwa A. [1 ]
Mohammed, Amany B. [1 ]
机构：
[1] Beni Suef Univ, Dept Med Chem, Fac Pharm, Bani Suwayf, Egypt
[2] Cairo Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 09期
关键词：
Pyrrolizines; Pyrimidopyrrolizines; Pyridopyrrolizines; Antitumor; INHIBITORS;
D O I：
10.1007/s00044-011-9761-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel series of pyrrolizines (7, 9a-d, 10a-d, 11a, b, 14a-d, 16, 19, 20a, b, 24, 25a, b), pyrimido[5,4-a]pyrrolizines (12a, b, 13, 15a, b, 18, 21a, b, 22, 23a-d) and pyrido[3,2-a]pyrrolizines (17, 26a, b) were synthesized through different reactions. The chemical structures of all the synthesized pyrrolizine derivatives were determined by spectral and elemental analyses. Antitumor activity evaluation of all the prepared compounds was carried out using NR assay method against breast cancer cell line (MCF-7). The novel pyrrolizine scaffold 7 and all its prepared derivatives showed high antitumor activity comparable to that of doxorubicin.
引用
收藏
页码：2349 / 2362
页数：14
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