Emotional arousal regulation of memory consolidation

被引:61
|
作者
McGaugh, James L. [1 ]
机构
[1] Univ Calif Irvine, Dept Neurobiol & Behav, Ctr Neurobiol Learning & Memory, Irvine, CA 92697 USA
关键词
INDUCED NORADRENERGIC ACTIVATION; AMYGDALA-HIPPOCAMPAL CONNECTIVITY; LONG-TERM-MEMORY; GLUCOCORTICOIDS INTERACT; ENHANCES CONSOLIDATION; ARC PROTEIN; MODULATION; EXPRESSION; RETRIEVAL; STRESS;
D O I
10.1016/j.cobeha.2017.10.003
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Recent findings provide increased understanding of how emotional arousal creates lasting memories. The findings are consistent with those of prior studies suggesting that the enhancement assessed in human subjects results from activation of adrenergic and glucocorticoid stress hormones. Additionally, fMRI imaging findings indicate that the enhancement is influenced by activation of the amygdala and its subsequent influences on other brain systems. Findings of recent animal studies using posttraining noradrenergic or optogenetic activation of the amygdala provide extensive evidence that the basolateral amygdala modulates memory consolidation by influencing neuroplasticity in downstream brain systems involved in processing different forms of memory. Activation of these systems helps to insure that emotionally significant experiences are well remembered.
引用
收藏
页码:55 / 60
页数:6
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