Management of epilepsy associated with tuberous sclerosis complex (TSC): Clinical recommendations

被引：122
|
作者：
Curatolo, Paolo [1 ]
Jozwiak, Sergiusz [2 ]
Nabbout, Rima [3 ]
机构：
[1] Univ Roma Tor Vergata, Dept Neurosci, Pediat Neurol Unit, I-00133 Rome, Italy
[2] Childrens Mem Hlth Inst, Dept Neurol & Epileptol, Warsaw, Poland
[3] Hop Necker Enfants Malad, Dept Neuropediat, Ctr Reference Epilepsies Rares, Paris, France
来源：
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2012年 / 16卷 / 06期
关键词：
Epilepsy; Tuberous sclerosis complex (TSC); Consensus; Clinical recommendations; mTOR; VAGUS NERVE-STIMULATION; INTRACTABLE EPILEPSY; INFANTILE SPASMS; MOUSE MODEL; SEIZURES; VIGABATRIN; EVEROLIMUS; CHILDREN; SURGERY;
D O I：
10.1016/j.ejpn.2012.05.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Tuberous sclerosis complex (TSC) is a leading genetic cause of epilepsy. TSC-associated epilepsy generally begins during the first year of life, and is associated with neurodevelopmental and cognitive problems. Management is challenging and seizures tend to persist in a large proportion of patients despite pharmacological and surgical treatment. This report summarizes the clinical recommendations for the management of TSC-associated epilepsy made by a panel of European experts in March 2012. Current treatment options and outstanding questions are outlined. (C) 2012 Published by Elsevier Ltd on behalf of European Paediatric Neurology Society.
引用
收藏
页码：582 / 586
页数：5
相关论文
共 50 条
  • [41] Tuberous sclerosis complex (TSC) with epilepsy on 18F-FDG simultaneous PET/MR
    Siwei Liu
    Yang Cai
    Rong Rong
    Pengcheng Hu
    Shuguang Chen
    Xin Wang
    Hongcheng Shi
    [J]. European Journal of Nuclear Medicine and Molecular Imaging, 2020, 47 : 2471 - 2472
  • [42] Quality of life in patients with Tuberous Sclerosis Complex (TSC)
    Amin, Sam
    Mallick, Andrew A.
    Lux, Andrew
    O'Callaghan, Finbar
    [J]. EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, 2019, 23 (06) : 801 - 807
  • [43] Biallelic TSC gene inactivation in tuberous sclerosis complex
    Crino, Peter B.
    Aronica, Eleonora
    Baltuch, Gordon
    Nathanson, Katherine L.
    [J]. NEUROLOGY, 2010, 74 (21) : 1716 - 1723
  • [44] CAUSES OF MORTALITY IN INDIVIDUALS WITH TUBEROUS SCLEROSIS COMPLEX (TSC)
    Amin, Sam
    Lux, Andrew
    Calder, Nuala
    Laugharne, Matthew
    Osborne, John
    O'Callaghan, Finbar
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2016, 87 (12):
  • [45] BRAIN MRI CHARACTERISTICS OF EPILEPTOGENIC TUBER AND PREDICTORS OF INTRACTABLE EPILEPSY IN TUBEROUS SCLEROSIS COMPLEX (TSC)
    Viravan, S.
    Velayudam, K.
    Kotagal, P.
    Lachhwani, K.
    Wyllie, E.
    Tuxhorn, I.
    Bingaman, W. E.
    Gupta, Ajay
    [J]. EPILEPSIA, 2009, 50 : 487 - 487
  • [46] Tuberous sclerosis complex (TSC) with epilepsy on 18F-FDG simultaneous PET/MR
    Liu, Siwei
    Cai, Yang
    Rong, Rong
    Hu, Pengcheng
    Chen, Shuguang
    Wang, Xin
    Shi, Hongcheng
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 47 (10) : 2471 - 2472
  • [47] Tuberous Sclerosis Complex (TSC): Renal and Extrarenal Imaging
    Gupta, Shiva
    Kang, Hyunseon C.
    Faria, Silvana C.
    Choyke, Peter L.
    Kundra, Vikas
    [J]. ACADEMIC RADIOLOGY, 2022, 29 (03) : 439 - 449
  • [48] Mutational analysis of the Tuberous Sclerosis Complex (TSC) genes
    Rendtorff, ND
    Mogensen, B
    Brondum-Nielsen, K
    Schwartz, M
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2002, 10 : 96 - 96
  • [49] TUBEROUS SCLEROSIS COMPLEX (TSC): A NORWEGIAN INTERDISCIPLINARY GUIDE
    Tuft, M.
    Olsen, T. Rath
    [J]. EPILEPSIA, 2015, 56 : 91 - 91
  • [50] Neuropsychological Attention Deficits in Tuberous Sclerosis Complex (TSC)
    de Vries, Petrus J.
    Gardiner, Julian
    Bolton, Patrick F.
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2009, 149A (03) : 387 - 395
12345