The therapeutic potential of IGF-I in skeletal muscle repair

被引：79
|
作者：
Song, Yao-Hua [1 ]
Song, Jenny L. [1 ]
Delafontaine, Patrice [2 ]
Godard, Michael P. [3 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Cyrus Tang Hematol Ctr, Suzhou 215123, Peoples R China
[2] Tulane Univ, Sch Med, Inst Heart & Vasc, New Orleans, LA 70112 USA
[3] Cent Missouri State Univ, Dept Nutr & Kinesiol, Warrensburg, MO 64093 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2013年 / 24卷 / 06期
关键词：
muscle wasting; IGF-I; satellite cell; GROWTH-FACTOR-I; AMYOTROPHIC-LATERAL-SCLEROSIS; SPINAL MUSCULAR-ATROPHY; 2-YEAR ALS TRIAL; MOUSE MODEL; CANCER CACHEXIA; HEART-FAILURE; STEM-CELLS; FUNCTIONAL RECOVERY; SUBCUTANEOUS IGF-1;
D O I：
10.1016/j.tem.2013.03.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Skeletal muscle loss due to aging, motor-neuron degeneration, cancer, heart failure, and ischemia is a serious condition for which currently there is no effective treatment. Insulin-like growth factor 1 (IGF-I) plays an important role in muscle maintenance and repair. Preclinical studies have shown that IGF-I is involved in increasing muscle mass and strength, reducing degeneration, inhibiting the prolonged and excessive inflammatory process due to toxin injury, and increasing the proliferation potential of satellite cells. However, clinical trials have not been successful due to ineffective delivery methods. Choosing the appropriate isoforms or peptides and developing targeted delivery techniques can resolve this issue. Here we discuss the latest development in the field with special emphasis on novel therapeutic approaches.
引用
收藏
页码：310 / 319
页数：10
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