MALDI-TOF Mass Spectrometry for Microorganism Identification

被引：151
|
作者：
Dingle, Tanis C. [1 ]
Butler-Wu, Susan M. [1 ]
机构：
[1] Univ Washington, Med Ctr, Dept Lab Med, Seattle, WA 98195 USA
来源：
CLINICS IN LABORATORY MEDICINE | 2013年 / 33卷 / 03期
关键词：
Mass spectrometry; Microbe identification; MALDI-TOF; Diagnosis; LASER-DESORPTION-IONIZATION; RESISTANT STAPHYLOCOCCUS-AUREUS; POSITIVE BLOOD CULTURES; RAPID IDENTIFICATION; DESORPTION/IONIZATION-TIME; METHICILLIN-RESISTANT; ROUTINE IDENTIFICATION; ANAEROBIC-BACTERIA; SPECIES IDENTIFICATION; INTACT MICROORGANISMS;
D O I：
10.1016/j.cll.2013.03.001
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid, reliable, and high-throughput diagnostic tool for the identification of microorganisms. The technology is unique in clinical microbiology, allowing laboratories to definitively identify bacterial and fungal isolates within minutes. The rapid turnaround time and minimal cost for consumables per specimen compared with conventional identification methods have resulted in MALDI-TOF MS being increasingly used in clinical laboratories worldwide. This article summarizes the current literature on MALDI-TOF MS for microbial identification and provides a preview of the method's potential future applications in clinical microbiology.
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页码：589 / +
页数：22
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