CTV-1-Activated CAR-NK (MBIO-109): A Potent "Off-The-Shelf" Tumoricidal Therapeutic

被引:0
|
作者
Joseph, Aviva [1 ]
Lin, Szu Hua Sharon [1 ]
Haso, Waleed [1 ]
Gumlaw, Nathan [1 ]
Lowdell, Mark [2 ]
Kassim, Sadik H. [3 ]
Patel, Ekta [1 ,4 ]
机构
[1] Mustang Bio, R&D, Worcester, MA USA
[2] Royal Free Hosp, Ctr Cell Gene & Tissue Therapeut, Inst Immun & Transplantat, London, England
[3] Mustang Bio, Worcester, MA USA
[4] Mustang Bio, Translat Res, Worcester, MA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
834
引用
收藏
页码:385 / 385
页数:1
相关论文
共 30 条
  • [21] FT555: Off-the-Shelf CAR-NK Cell Therapy Co-Targeting GPRC5D and CD38 for the Treatment of Multiple Myeloma
    Reiser, John
    Chan, Szeman Ruby
    Mathavan, Ketan
    Sillitti, David
    Mottershead, Cristina
    Mattson, Bethany
    Pache, Melissandre
    Gutierrez, Alma
    Scoon, Whitney
    Zhu, Yanni
    Gilder, Andrew
    Chen, Christine
    Staquet, Kimberly
    Ports, Michael
    Drake, Charles
    Erhardt, Joseph
    Bjordahl, Ryan
    Goodridge, Jode P.
    Valamehr, Bahram
    BLOOD, 2022, 140 : 4560 - 4561
  • [22] Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin
    Zheng, Liuhai
    Wang, Huifang
    Zhou, Jihao
    Shi, Guangwei
    Ma, Jingbo
    Jiang, Yuke
    Dong, Zhiyu
    Li, Jiexuan
    He, Yuan-Qiao
    Wu, Dinglan
    Sun, Jichao
    Xu, Chengchao
    Li, Zhijie
    Wang, Jigang
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2024, 12 (07)
  • [23] Preclinical development of SENTI-202, an off-the-shelf logic gated CAR-NK cell therapy, for the treatment of CD33/FLT3+hematologic malignancies including AML
    Gonzalez, Alba
    Hong, Enping
    Yucel, Gozde
    Leitner, Elizabeth
    Chinta, Pearley
    Deng, Han
    Li, Ian
    Lam, Alice
    Bakir, Abla
    Lee, Brandon
    Chakraborty, Papia
    Blanco, Carmina
    Lee, Chen-Ting
    Almudhfar, Niran
    Tian, Mengxi
    Song, Wenqi
    Banicki, Andrew
    Contreras, Otto
    Gieldin, Martin
    Garrison, Brian
    Lu, Timothy K.
    Rajangam, Kanya
    CANCER RESEARCH, 2023, 83 (07)
  • [24] NKX101, an allogeneic off-the-shelf NKG2D CAR-NK cell therapy, has potent in vitro cytotoxicity against patient-derived AML leukemic stem cells and non-leukemic stem cell blasts
    Hansen, Kyle
    Cho, Cynthia
    Kothari, Nishi
    Shook, David
    Trager, James
    CANCER RESEARCH, 2024, 84 (06)
  • [25] The "off-the-shelf "CD19-CAR-V δ 1T cells demonstrated an enhanced therapeutic effect on B-cell malignancy models
    Chen, Dan
    You, Fengtao
    Chen, Cheng
    Zhang, Ping
    Wu, Hai
    Zheng, Zhong
    Wang, Min
    Wang, Xingbing
    Meng, Huimin
    Yang, Nan
    Zhang, Bozhen
    Yang, Lin
    CANCER RESEARCH, 2024, 84 (06)
  • [26] Senti-202, a Selective, Off-the-Shelf, Preclinical CAR-NK Cell Therapy with CD33 and/or FLT3 Activating CAR, Healthy Cell Protection from Endomucin (EMCN) Inhibitory CAR and Calibrated Release IL-15 for Hematologic Malignancies Including AML
    Garrison, Brian
    Deng, Han
    Yucel, Gozde
    Frankel, Nicholas W.
    Gordley, Russell
    Hung, Michelle
    Lee, Derrick
    Gainer, Marcus
    Roguev, Assen
    Gorman, Wesley
    Leemans, Nelia
    Lam, Alice
    Li, Yongshuai
    Wong, Wilson
    Rajangam, Kanya L.
    Lee, Philip
    Lu, Tim
    BLOOD, 2022, 140 : 4531 - 4532
  • [27] NKX101, an Allogeneic Off-the-Shelf CAR NK Cell Therapy Targeting NKG2D-Ls, Has Potent Anti-Leukemic Activity Alone or in Combination with Ara-C
    Cho, Cynthia
    Hansen, Kyle
    Kimura, Nikki
    Sood, Jessica
    Juat, Damie
    Geng, Tao
    Trager, James
    BLOOD, 2023, 142
  • [28] NKX101, an allogeneic off-the-shelf CAR NK cell therapy targeting NKG2D-Ls, has potent anti-leukemic activity alone or in combination with Ara-C
    Cho, Cynthia
    Kimura, Nikki
    Sood, Jessica
    Juat, Damie
    Zhang, Max
    Chan, Carmel
    Geng, Tao
    Hansen, Kyle
    Trager, James
    CANCER RESEARCH, 2024, 84 (06)
  • [29] FT576: Multi-Specific Off-the-Shelf CAR-NK Cell Therapy Engineered for Enhanced Persistence, Avoidance of Self-Fratricide and Optimized Mab Combination Therapy to Prevent Antigenic Escape and Elicit a Deep and Durable Response in Multiple Myeloma
    Goodridge, Jode P.
    Bjordahl, Ryan
    Mahmood, Sajid
    Reiser, John
    Gaidarova, Svetlana
    Blum, Robert
    Cichocki, Frank
    Chu, Hui-yi
    Bonello, Greg
    Lee, Tom
    Groff, Brian
    Meza, Miguel
    Chu, Yu-Waye
    Walcheck, Bruce
    Malmberg, Karl-Johan
    Miller, Jeffrey S.
    Rehm, Armin
    Hopken, Uta
    Valamehr, Bahram
    BLOOD, 2020, 136
  • [30] NKX101, an Allogeneic Off-the-Shelf CAR NK Therapy Targeting NKG2D-Ls, Has Potent In Vitro Cytotoxicity Against Patient-Derived AML Leukemic Stem Cell (LSC) and Non-Leukemic Stem Cell (Non-LSC) Blasts
    Hansen, Kyle
    Cho, Cynthia
    Mehta, Nishi
    Shook, David
    Trager, James
    BLOOD, 2023, 142