Novel methods of synthesizing naphtho[1,2-c]furan-1,3-dione and benzo[e]isoindole-1,3-dione

被引：3
|
作者：
Mizuno, M [1 ]
Yamano, M [1 ]
机构：
[1] Takeda Pharmaceut Co Ltd, Div Pharmaceut Prod, Chem Dev Labs, Yodogawa Ku, Osaka 5328686, Japan
来源：
HETEROCYCLES | 2006年 / 67卷 / 02期
关键词：
D O I：
10.3987/COM-05-S(T)78
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Convenient methods of synthesizing naphtho[1,2-c]furan-1,3-dione and benzo[e]isoindole-1,3-dione from phenylbutyric acid derivatives have been established. Naphtho[1,2-c]furan-1,3-dione and benzo[e]isoindole-1,3-dione were obtained respectively from 4,5-dihydronaphtho[1,2-c]furan-1,3-dione and 4,5-dihydrobenzo[e]isoindole-1,3-dione by aromatization with 10% Pd-C in AcOH under mild conditions. In addition, benzo[e]isoindole-1,3-dione derivatives were obtained from 4,5-dihydronaphtho [ 1,2-c] furan-1,3 -dione by imidation and simultaneous aromatization with primary amine in AcOH in one pot.
引用
收藏
页码：807 / +
页数：9
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