Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes

被引：257

作者：

Mucida, Daniel ^{[1
]}

Husain, Mohammad Mushtaq ^{[1
]}

Muroi, Sawako ^{[2
]}

van Wijk, Femke ^{[1
]}

Shinnakasu, Ryo ^{[1
]}

Naoe, Yoshinori ^{[2
]}

Reis, Bernardo Sgarbi ^{[3
]}

Huang, Yujun ^{[1
]}

Lambolez, Florence ^{[1
]}

Docherty, Michael ^{[1
]}

Attinger, Antoine ^{[1
]}

Shui, Jr-Wen ^{[1
]}

Kim, Gisen ^{[1
]}

Lena, Christopher J. ^{[1
]}

Sakaguchi, Shinya ^{[4
]}

Miyamoto, Chizuko ^{[2
]}

Wang, Peng ^{[5
]}

Atarashi, Koji ^{[6
]}

Park, Yunji ^{[1
]}

Nakayama, Toshinori ^{[7
]}

Honda, Kenya ^{[6
]}

Ellmeier, Wilfried ^{[4
]}

Kronenberg, Mitchell ^{[1
]}

Taniuchi, Ichiro ^{[2
]}

Cheroutre, Hilde ^{[1
]}

机构：

[1] La Jolla Inst Allergy Immunol, Div Dev Immunol, La Jolla, CA 92037 USA

[2] RIKEN Res Ctr Allergy & Immunol, Lab Transcript Regulat, Yokohama, Kanagawa, Japan

[3] Rockefeller Univ, Lab Mucosal Immunol, New York, NY 10021 USA

[4] Med Univ Vienna, Ctr Physiol Pathophysiol & Immunol, Inst Immunol, Vienna, Austria

[5] La Jolla Inst Allergy Immunol, Div Vaccine Discovery, La Jolla, CA USA

[6] Univ Tokyo, Grad Sch Med, Dept Immunol, Tokyo, Japan

[7] Chiba Univ, Grad Sch Med, Dept Immunol, Chiba, Japan

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 03期

基金：

美国国家卫生研究院; 日本学术振兴会; 奥地利科学基金会;

关键词：

INTESTINAL INTRAEPITHELIAL LYMPHOCYTES; CD8; INTERLEUKIN-15; EXPRESSION; DIFFERENTIATION; IDENTIFICATION; REPRESSION; RESPONSES; GATA-3; THPOK;

D O I：

10.1038/ni.2523

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TCR alpha beta thymocytes differentiate into either CD8 alpha beta(+) cytotoxic T lymphocytes or CD4(+) helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic program in major histocompatibility complex (MHC) class II-restricted CD4(+) thymocytes. ThPOK continues to repress genes of the CD8 lineage in mature CD4(+) T cells, even as they differentiate into effector helper T cell subsets. Here we found that the helper T cell fate was not fixed and that mature, antigen-stimulated CD4(+) T cells terminated expression of the gene encoding ThPOK and reactivated genes of the CD8 lineage. This unexpected plasticity resulted in the post-thymic termination of the helper T cell program and the functional differentiation of distinct MHC class II-restricted CD4(+) cytotoxic T lymphocytes.

引用

页码：281 / 289

页数：9

共 50 条

[31] Mature CD4+ T cells perceive a positively selecting class II MHC/peptide complex in the periphery
Muranski, P
Chmielowski, B
Ignatowicz, L
JOURNAL OF IMMUNOLOGY, 2000, 164 (06): : 3087 - 3094
[32] Peptide Modification Diminishes HLA Class II-restricted CD4+ T Cell Recognition of Prostate Cancer Cells
Doonan, Bently P.
Amria, Shereen
Bethard, Jennifer R.
Banik, Narendra L.
Hathaway-Schrader, Jessica D.
Haque, Azizul
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
[33] CLASS-II MHC-RESTRICTED HELPER T-CELLS IN CD4-DEFICIENT MICE
RAHEMTULLA, A
KUNDIG, T
NARENDRAN, A
JULIUS, M
PAIGE, C
ZINKERNAGEL, R
MAK, T
JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 458 - 458
[34] EVIDENCE OF A ROLE FOR TNF-ALPHA IN CYTOLYSIS BY CD4+, CLASS-II MHC-RESTRICTED CYTOTOXIC T-CELLS
TITE, JP
IMMUNOLOGY, 1990, 71 (02) : 208 - 212
[35] Giving CD4+T cells the slip: viral interference with MHC class II-restricted antigen processing and presentation
Forsyth, Katherine S.
Eisenlohr, Laurence C.
CURRENT OPINION IN IMMUNOLOGY, 2016, 40 : 123 - 129
[36] Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation
Spierings, E
Vermeulen, CJ
Vogt, MH
Doerner, LEE
Falkenburg, JHF
Mutis, T
Goulmy, E
LANCET, 2003, 362 (9384): : 610 - 615
[37] On the self-referential nature of naive MHC class II-restricted T cells
Viret, C
He, X
Janeway, CA
JOURNAL OF IMMUNOLOGY, 2000, 165 (11): : 6183 - 6192
[38] MHC II-RESTRICTED, CD4+ CYTOTOXIC T-LYMPHOCYTES SPECIFIC FOR HERPES-SIMPLEX VIRUS-1 - IMPLICATIONS FOR THE DEVELOPMENT OF HERPETIC STROMAL KERATITIS IN MICE
DOYMAZ, MZ
FOSTER, CM
DESTEPHANO, D
ROUSE, BT
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1991, 61 (03): : 398 - 409
[39] Impact of MHC class II polymorphism on blood counts of CD4+ T lymphocytes in macaque
Alice Aarnink
Henri-Jean Garchon
Bénédicte Puissant-Lubrano
Marie Blancher-Sardou
Pol-André Apoil
Antoine Blancher
Immunogenetics, 2011, 63 : 95 - 102
[40] Post-thymic selection of peripheral CD4+ T lymphocytes on mhc class II
Shen, XL
König, R
FASEB JOURNAL, 2000, 14 (06): : A1223 - A1223

← 1 2 3 4 5 →