Highly Chemoselective Metal-Free Reduction of Phosphine Oxides to Phosphines

被引：159

作者：

Li, Yuehui ^{[1
]}

Lu, Liang-Qiu ^{[1
]}

Das, Shoubhik ^{[1
]}

Pisiewicz, Sabine ^{[1
]}

Junge, Kathrin ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 44期

关键词：

NEUTRAL COORDINATE-ORGANOCATALYSTS; CATALYZED REDUCTION; STEREOSPECIFIC DEOXYGENATION; BISPHOSPHINE LIGANDS; CARBONYL-COMPOUNDS; BIDENTATE LIGANDS; SILANE REDUCTIONS; FUNCTIONAL-GROUP; REDUCING AGENT; CHIRAL LIGAND;

D O I：

10.1021/ja3069165

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Unprecedented chemoselective reductions of phosphine oxides to phosphines proceed smoothly in the presence of catalytic amounts of specific Bronsted acids. By utilizing inexpensive silanes, e.g., PMHS or (EtO)(2)MeSiH, other reducible functional groups such as ketones, aldehydes, olefins, nitriles, and esters are well-tolerated under optimized conditions.

引用

页码：18325 / 18329

页数：5

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