Oxidation and Reduction of the 5-(2-Deoxyuridinyl)methyl Radical

被引：45
|
作者：
Lin, Gengjie [1 ]
Li, Lei [1 ,2 ]
机构：
[1] IUPUI, Dept Chem & Chem Biol, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 21期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
DNA; photochemistry; radicals; reaction mechanisms; thymine; CROSS-LINK FORMATION; AQUEOUS-SOLUTIONS; GAMMA-RADIOLYSIS; INDEPENDENT GENERATION; THERMAL-DECOMPOSITION; SODIUM DITHIONITE; NUCLEIC-ACIDS; DNA; THYMIDINE; REACTIVITY;
D O I：
10.1002/anie.201209454
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Sleeping beauty: The 5-(2-Deoxyuridinyl)methyl radical 1 is a key intermediate in the thymine oxidative reaction mediated by reactive oxygen species. Evidence is presented that 1 is prone to both oxidation and reduction reactions at the absence of O2. These results question the current paradigm and suggest that the redox chemistry of 1, which has been largely overlooked in the past, may play a major role in determining the fate of 1. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：5594 / 5598
页数：5
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