Behavioral effects of ivermectin in mice

被引:0
|
作者
Davis, JA
Paylor, R
McDonald, MP
Libbey, M
Ligler, A
Bryant, K
Crawley, JN
机构
[1] NINDS, Anim Hlth Care Sect, NIH, Bethesda, MD 20892 USA
[2] NIMH, Sect Behav Neuropharmacol, Expt Therapeut Branch, NIH, Bethesda, MD USA
来源
LABORATORY ANIMAL SCIENCE | 1999年 / 49卷 / 03期
关键词
D O I
暂无
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Background and Purpose: Ivermectin is a common anthelmintic drug, widely used in laboratory rodents for treatment of pinworm and mite infestations. We evaluated the action of ivermectin on sensitive behavioral tasks in mice during treatment for mites within a barrier facility. Methods: A total of 21 (5 males, 16 females) mice (129/SvEv) were used for measuring body weight, open field locomotor activity, and rotarod motor coordination. For acoustic startle and prepulse inhibition, 20 C57BL/6J and 29 AKR/J mice were studied. For the Morris water task, the same 20 C57BL/6J mice were studied. Ivermectin (0.08% sheep drench) was administered in the drinking water of the home cage for 8 weeks. Control groups received normal tap water in identical bottles. Results: Ivermectin did not affect general health, body weight, motor coordination, swimming behavior, or spatial learning in several inbred strains of mice. However, it induced a small but significant effect on some sensitive behaviors. Conclusions: A cautious approach to initiating ivermectin treatment in mice should be used for sensitive behavioral experiments.
引用
收藏
页码:288 / 296
页数:9
相关论文
共 50 条
  • [21] IMMUNOLOGICAL AND BEHAVIORAL-EFFECTS OF FRAGRANCE IN MICE
    SHIBATA, H
    FUJIWARA, R
    IWAMOTO, M
    MATSUOKA, H
    YOKOYAMA, MM
    INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1991, 57 (1-2) : 151 - 159
  • [22] Effects of litter size on behavioral development in mice
    Tanaka, T
    REPRODUCTIVE TOXICOLOGY, 1998, 12 (06) : 613 - 617
  • [23] THE BEHAVIORAL-EFFECTS OF INTRAVENOUS TRYPTAMINE IN MICE
    YAMADA, J
    SUGIMOTO, Y
    HORISAKA, K
    FOLIA PHARMACOLOGICA JAPONICA, 1986, 88 (01) : P25 - P25
  • [24] Prenatal effects of parity on behavioral ontogeny in mice
    Crusio, WE
    Schmitt, A
    PHYSIOLOGY & BEHAVIOR, 1996, 59 (06) : 1171 - 1174
  • [25] BEHAVIORAL-EFFECTS OF MAMMALIAN ALKALOIDS IN MICE
    COLLINS, MA
    MEISENBERG, G
    SIMMONS, W
    FEDERATION PROCEEDINGS, 1983, 42 (04) : 883 - 883
  • [26] Behavioral and neurochemical effects induced by reserpine in mice
    Catiuscia Molz de Freitas
    Alcindo Busanello
    Larissa Finger Schaffer
    Luis Ricardo Peroza
    Bárbara Nunes Krum
    Caroline Queiroz Leal
    Ana Paula Chiapinotto Ceretta
    João Batista Teixeira da Rocha
    Roselei Fachinetto
    Psychopharmacology, 2016, 233 : 457 - 467
  • [27] Behavioral and radioprotective effects of misoprostol in adrenalectomized mice
    Landauer, MR
    Weiss, JF
    Gunter-Smith, PJ
    Benson, KA
    Blair, MD
    Hogan, JB
    Hanson, WR
    EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION, AND RADIATION INJURY 2, PTS A AND B, 1997, 400 : 799 - 804
  • [28] Cognitive and behavioral effects of brief seizures in mice
    Batterman, Alexander, I
    DeChiara, James
    Islam, Ariful
    Brenner, Megan B.
    Fischer, Bradford D.
    Buono, Russell J.
    Keck, Thomas M.
    Ferraro, Thomas N.
    EPILEPSY & BEHAVIOR, 2019, 98 : 249 - 257
  • [29] EFFECTS OF CYCLOHEXIMIDE ON UNRESTRICTED BEHAVIORAL PATTERNS OF MICE
    SCHNEIDER, CW
    CHENOWETH, MB
    BRAIN RESEARCH, 1971, 25 (03) : 625 - +
  • [30] Physiologic and Behavioral Effects of Environmental Vibration in Mice
    Olsen, A. L.
    Shahan, T.
    Folkman, S.
    JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE, 2010, 49 (05): : 655 - 655