An analysis of the blood pressure and safety outcomes to renal denervation in African Americans and Non-African Americans in the SYMPLICITY HTN-3 trial

被引：34

作者：

Flack, John M. ^{[1
]}

Bhatt, Deepak L. ^{[2
]}

Kandzari, David E. ^{[3
]}

Brown, David ^{[4
]}

Brar, Sandeep ^{[5
]}

Choi, James W. ^{[6
]}

D'Agostino, Ralph ^{[7
]}

East, Cara ^{[6
]}

Katzen, Barry T. ^{[7
]}

Lee, Lilian ^{[5
]}

Leon, Martin B. ^{[8
,9
]}

Mauri, Laura ^{[10
]}

O'Neill, William W. ^{[11
]}

Oparil, Suzanne ^{[12
]}

Rocha-Singh, Krishna ^{[13
]}

Townsend, Raymond R. ^{[14
]}

Bakris, George ^{[15
]}

机构：

[1] So Illinois Univ, Div Gen Med, Dept Med, Hypertens Sect, Springfield, IL 62794 USA

[2] Harvard Univ, Brigham & Womens Hosp, Heart & Vasc Ctr, Sch Med, Boston, MA 02115 USA

[3] Piedmont Heart Inst, Div Cardiol, Dept Med, Atlanta, GA USA

[4] Heart Hosp Baylor Plano, Cardiovasc Div, Dept Med, Plano, TX USA

[5] Medtron CardioVasc, Clin Dept, Santa Rosa, CA USA

[6] Heart & Vasc Hosp, Baylor Soltero Cardiovasc Res Ctr, Dallas, TX USA

[7] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

[8] Columbia Univ, Dept Med, Div Cardiol, New York Presbyterian Hosp,Med Ctr, New York, NY USA

[9] Cardiovasc Res Fdn, New York, NY USA

[10] Harvard Clin Res Inst, Div Cardiol, Dept Med, Boston, MA USA

[11] Henry Ford Detroit Hosp, Div Cardiol, Dept Med, Detroit, MI USA

[12] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA

[13] St Johns Hosp, Prairie Heart Inst, Springfield, IL USA

[14] Univ Penn, Dept Med, Div Renal, Perelman Sch Med, Philadelphia, PA 19104 USA

[15] Univ Chicago Med, Hypertens Dis Ctr, Chicago, IL USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION | 2015年 / 9卷 / 10期

关键词：

Renal denervation; African American; uncontrolled apparent treatment-resistant hypertension; TREATMENT-RESISTANT HYPERTENSION; UNITED-STATES; SYMPATHETIC DENERVATION; DISEASE; CIRCULATION; PREVALENCE; ETHNICITY; ADHERENCE; SYSTEM; HEALTH;

D O I：

10.1016/j.jash.2015.08.001

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

SYMPLICITY HTN-3, the first trial of renal denervation (RDN) versus sham, enrolled 26% African Americans, a prospectively stratified cohort. Although the 6-month systolic blood pressure (SBP) reduction in African Americans (AAs) was similar in the RDN group (-15.5 +/- 25.4 mm Hg, n = 85 vs. -17.8 +/- 29.2, n = 49, P =.641), the sham SBP response was 9.2 mm Hg greater (P =.057) in AAs than non-AAs. In multivariate analyses, sham SBP response was predicted by an interaction between AA and a complex antihypertensive regimen (at least one antihypertensive medication prescribed >= 3 times daily), while in the RDN group, SBP response was predicted by an interaction between AA race and baseline BP >= 180 mm Hg. AA race did not independently predict SBP response in either sham or RDN. There appears to be effect modification by race with individual-level patient characteristics in both treatment aims that affect the observed pattern of SBP responses. (C) 2015 American Society of Hypertension. All rights reserved.

引用

页码：769 / 779

页数：11

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