Detection of Thyroid Abnormalities in Aquaporin-4 Antibody-Seropositive Optic Neuritis Patients

Objective: This study retrospectively analyzed the frequency of anti-thyroid antibodies (ATAs) and thyroid disease in patients with optic neuritis (ON). Methods: Tests of serum thyroglobulin (TG) and thyroid peroxidase (TPO) antibodies and thyroid function were performed in 97 ON patients. Blood also was drawn to test for AQP4-Ab using cell-based and enzyme-linked immunosorbent assays. Comparisons of the frequencies of ATAs, thyroid diseases and thyroid function were performed based on AQP4-Ab status. Results: Seropositive AQP4-Ab was found in 47/97 (48.5%) patients. ATA was considered positive in 34/97 (35.1%) patients. The prevalence of ATA was two times higher (P= 0.019) in the AQP4-Ab+group compared to the AQP4-Ab-group. AQP4-Ab+ON patients exhibited lower FT3 (P= 0.006) and FT4 (P=0.025) levels and a higher prevalence of definite Hashimoto thyroiditis (HT) (P=0.005). Among AQP4-Ab+patients, those with HT had a worse visual outcome than non-HT patients. Conclusion: A high prevalence of ATAs and HT was found in AQP4-Ab+ON patients, and AQP4-Ab+patients with HT exhibited worse visual outcomes than non-HT patients. (C) 2016 by North American Neuro-Ophthalmology Society