Novel Biphenyl Derivatives with α-Aminophosphonate Moiety: Design, Synthesis and Antivirus Activity

A series of novel biphenyl derivatives with alpha-aminophosphonate moiety was designed and successively synthesized through Suzuki-Miyaura and Kabachnik-Fields reaction. The structures of the target compounds were confirmed by H-1 NMR, C-13 NMR, P-31 NMR, IR and H MRS. The antiviral activity against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) indicated that most of the target compounds exhibited certain anti-TMV and good anti-CMV activities, respectively, in which compound 4d displayed higher anti-TMV activity and compound 4s exhibited higher anti-CMV activity than the commercial agent Ningnanmycin.