Metallation of methoxy-2(1H)-quinolinones

被引：0

作者：

Moreno, T

Fernandez, M

delaCuesta, E

Avendano, C

机构：

来源：

HETEROCYCLES | 1996年 / 43卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methoxy group at 5- or 6-position of 2(1H)-quinolinones is compatible with the regioselective electrophilic substitution and chain enlargement at the 3-position imposed by the ortho-directed effect of the quinolinone lithium sail. The coordination effect of a methoxy group at the 8-position changes the reaction course, precluding the ortho-directed metallation and enhancing the conjugate addition at the 4-position.

引用

页码：817 / 828

页数：12

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