Metallation of methoxy-2(1H)-quinolinones

被引：0
|
作者：
Moreno, T
Fernandez, M
delaCuesta, E
Avendano, C
机构：
来源：
HETEROCYCLES | 1996年 / 43卷 / 04期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methoxy group at 5- or 6-position of 2(1H)-quinolinones is compatible with the regioselective electrophilic substitution and chain enlargement at the 3-position imposed by the ortho-directed effect of the quinolinone lithium sail. The coordination effect of a methoxy group at the 8-position changes the reaction course, precluding the ortho-directed metallation and enhancing the conjugate addition at the 4-position.
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页码：817 / 828
页数：12
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