Synthesis and Biological Applications of Phosphinates and Derivatives

被引：30

作者：

Virieux, David ^{[1
]}

Volle, Jean-Noel ^{[1
]}

Bakalara, Norbert ^{[2
]}

Pirat, Jean-Luc ^{[1
]}

机构：

[1] ENSCM, UMR ICG Montpellier 5253, Equipe AM2N, F-34296 Montpellier 5, France

[2] INSERM, U1051, Inst Neurosci Montpellier, F-34091 Montpellier, France

来源：

PHOSPHORUS CHEMISTRY I: ASYMMETRIC SYNTHESIS AND BIOACTIVE COMPOUNDS | 2015年 / 360卷

关键词：

Bioisostere; Phosphinate; Phosphinic acid; Tetrahedral transition state; HUMAN FOLYLPOLYGLUTAMATE SYNTHETASE; BETAINE-HOMOCYSTEINE METHYLTRANSFERASE; CATALYZED DEHYDRATIVE ALLYLATION; METABOTROPIC GLUTAMATE RECEPTORS; CROSS-COUPLING REACTIONS; ANTI-HIV ACTIVITY; PYRUVATE-DEHYDROGENASE; HERBICIDAL ACTIVITY; POTENT INHIBITORS; GAMMA-GLUTAMATE;

D O I：

10.1007/128_2014_566

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review first outlines general considerations on phosphinic acids and derivatives as bioisosteric groups. The next sections present key aspects of phosphinic acid-based molecules and include a brief description of the biological pathways involved for their activities. The synthetic aspects and the biological activities of such compounds reported in the literature between 2008 and 2013 are also described.

引用

页码：39 / 114

页数：76

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