HIV-1 integrase inhibition of biscoumarin analogues

被引：75
|
作者：
Su, Chang-Xiao
Mouscadet, Jean-Francois
Chiang, Chih-Chia
Tsai, Hou-Jen
Hsu, Ling-Yih [1 ]
机构：
[1] Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan
[2] Ecole Normale Super, CNRS, UMR 8532, LBPA, F-92335 Cachan, France
[3] Chung Cheng Inst Technol, Dept Appl Chem, Tao Yuan 335, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 05期
关键词：
biscoumarins; HIV-1; integrase; inhibitor;
D O I：
10.1248/cpb.54.682
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nineteen biscoumarins bearing free and modified hydroxyl substituents at benzoyloxyphenyl linker have been synthesized by multiple step synthesis. Among these biscoumarins, thirteen were found to be active molecules against HIV-1 integrase (HIV-1 IN). The structure-activity relationship of the nineteen compounds on HIV IN may be useful for the design of potent therapeutic agents.
引用
收藏
页码：682 / 686
页数：5
相关论文
共 50 条
  • [31] HIV-1 integrase inhibition by pyrrole/imidazole-containing polyamides
    Zakharova, OD
    Baranova, S
    Parissi, V
    Ryabinin, VA
    Sinyakov, AN
    Litvak, S
    Litvak, LT
    Nevinsky, GA
    [J]. JOURNAL OF PEPTIDE RESEARCH, 2005, 66 : 138 - 145
  • [32] Inhibition of HIV-1 integrase dimerization and activity with crosslinked interfacial peptides
    Zhao, Lei
    Chmielewski, Jean
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (14) : 4041 - 4044
  • [33] HIV-1 integrase inhibition by dimeric bisbenzimidazoles with different spacer structures
    Korolev, S. P.
    Tashlitsky, V. N.
    Smolov, M. A.
    Gromyko, A. V.
    Zhuze, A. L.
    Agapkina, Yu. Yu.
    Gottikh, M. B.
    [J]. MOLECULAR BIOLOGY, 2010, 44 (04) : 633 - 641
  • [34] Inhibition of the Activity of Recombinant HIV-1 Integrase by Derivatives of Higher Terpenoids
    E. A. Semenova
    O. A. Plyasunova
    N. I. Petrenko
    N. V. Uzenkova
    E. E. Shul'ts
    G. A. Tolstikov
    A. G. Pokrovskii
    [J]. Doklady Biochemistry and Biophysics, 2003, 391 (1-6) : 218 - 220
  • [35] Inhibition of matrix metalloproteinases by HIV-1 integrase strand transfer inhibitors
    Foster, Emma G. G.
    Palermo, Nicholas Y. Y.
    Liu, Yutong
    Edagwa, Benson
    Gendelman, Howard E. E.
    Bade, Aditya N. N.
    [J]. FRONTIERS IN TOXICOLOGY, 2023, 5
  • [36] Integrase and integration: biochemical activities of HIV-1 integrase
    Olivier Delelis
    Kevin Carayon
    Ali Saïb
    Eric Deprez
    Jean-François Mouscadet
    [J]. Retrovirology, 5
  • [37] Dicaffeoyltartaric acid analogues inhibit human immunodeficiency virus type 1 (HIV-1) integrase and HIV-1 replication at nontoxic concentrations
    Reinke, RA
    King, PJ
    Victoria, JG
    McDougall, BR
    Ma, GX
    Mao, YQ
    Reinecke, MG
    Robinson, WE
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (17) : 3669 - 3683
  • [38] DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE ANALOGUES AS HIV-1 INTEGRASE INHIBITOR
    Deo, K. D.
    Singhvi, I. J.
    Murugesan, S.
    Vadnere, G. P.
    Patil, A. V.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2020, 11 (03): : 1210 - 1223
  • [39] Multimodal Functionalities of HIV-1 Integrase
    Engelman, Alan N.
    Kvaratskhelia, Mamuka
    [J]. VIRUSES-BASEL, 2022, 14 (05):
  • [40] The hunt for HIV-1 integrase inhibitors
    Lataillade, Max
    Kozal, Michael J.
    [J]. AIDS PATIENT CARE AND STDS, 2006, 20 (07) : 489 - 501
12345