HIV-1 integrase inhibition of biscoumarin analogues

被引：75
|
作者：
Su, Chang-Xiao
Mouscadet, Jean-Francois
Chiang, Chih-Chia
Tsai, Hou-Jen
Hsu, Ling-Yih [1 ]
机构：
[1] Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan
[2] Ecole Normale Super, CNRS, UMR 8532, LBPA, F-92335 Cachan, France
[3] Chung Cheng Inst Technol, Dept Appl Chem, Tao Yuan 335, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 05期
关键词：
biscoumarins; HIV-1; integrase; inhibitor;
D O I：
10.1248/cpb.54.682
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nineteen biscoumarins bearing free and modified hydroxyl substituents at benzoyloxyphenyl linker have been synthesized by multiple step synthesis. Among these biscoumarins, thirteen were found to be active molecules against HIV-1 integrase (HIV-1 IN). The structure-activity relationship of the nineteen compounds on HIV IN may be useful for the design of potent therapeutic agents.
引用
收藏
页码：682 / 686
页数：5
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