Collagen cross-linking in thin corneas

被引:11
|
作者
Padmanabhan, Prema [1 ]
Dave, Abhishek [1 ]
机构
[1] Sankara Nethralaya, Med Res Fdn, Dept Cataract Cornea & Refract Surg, Chennai 600006, Tamil Nadu, India
关键词
Corneal collagen cross-linking; hypoosmolar riboflavin; keratoconus; thin cornea; transepithelial collagen cross-linking; HYPOOSMOLAR RIBOFLAVIN SOLUTION; EPITHELIAL DEBRIDEMENT; ULTRAVIOLET-A;
D O I
10.4103/0301-4738.116073
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Collagen cross-linking (CXL) has become the standard of care for progressive keratoconus, after numerous clinical studies have established its efficacy and safety in suitably selected eyes. The standard protocol is applicable in eyes which have a minimum corneal thickness of 400 m after epithelial debridement. This prerequisite was stipulated to protect the corneal endothelium and intraocular tissues from the deleterious effect of ultraviolet-A (UVA) radiation. However, patients with keratoconus often present with corneal thickness of less than 400 m and could have otherwise benefited from this procedure. A few modifications of the standard procedure have been suggested to benefit these patients without a compromise in safety. Transepithelial cross-linking, pachymetry-guided epithelial debridement before cross-linking, and the use of hypoosmolar riboflavin are some of the techniques that have been attempted. Although clinical data is limited at the present time, these techniques are worth considering in patients with thin corneas. Further studies are needed to scientifically establish their efficacy and safety.
引用
收藏
页码:422 / 424
页数:3
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