Corneal thickness measured by Scheimpflug imaging in children with Down syndrome

PURPOSE To measure corneal thickness via the use of a Scheimpflug imaging system (OCULUS Optikgerate GmbH, Wetzlar, Germany) in children with Down syndrome. METHODS This prospective, nonrandomized, clinical trial included children with Down syndrome and age- and sex-matched healthy controls. All subjects received a complete ophthalmologic examination. Corneal topography measurements were acquired by means of Scheimpflug imaging. Central. corneal thickness (CCT), thinnest point of cornea (TP), and corneal volume (CV) were analyzed. RESULTS A total of 27 children with Down syndrome and 37 control subjects were included in the study. In children with Down syndrome, the mean CCT was 494.27 +/- 47 mu m, the mean TP was 487 +/- 49 mu m, and the mean CV was 56.2 +/- 6. In the controls, the mean CCT was 539.3 +/- 40 mu m, the mean TP was 538.0 +/- 40.8 mu m, and the mean CV was 61.3 +/- 4. For all 3 parameters, the difference was statistically significant (P < 0.001). In the Down syndrome group, the CCT was <500 mu m in 16 subjects (59.2%) and <450 mu m in 5 (18.5%). In the control group, the CCT was <500 mu m in 14 subjects (37.8%) and <450 mu m in 2 (5.4%). CONCLUSIONS In this study, corneal thickness was less in children with Down syndrome than in healthy control subjects. Decreased corneal thickness may be an early sign of a degenerative corneal disease such as keratoconus in children with Down syndrome.