PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits

被引：20
|
作者：
Wang, Qi [1 ,2 ]
Zhang, Pingzhao [1 ,2 ]
Zhang, Wei [1 ,2 ]
Zhang, Xin [1 ,2 ]
Chen, Jianfeng [1 ,2 ]
Ding, Peipei [1 ,2 ]
Li, Luying [1 ,2 ]
Lv, Xinyue [1 ,2 ]
Li, Ling [1 ,2 ]
Hu, Weiguo [1 ,2 ]
机构：
[1] Fudan Univ, Fudan Univ Shanghai Canc Ctr, Shanghai 200032, Peoples R China
[2] Fudan Univ, Inst Biomed Sci, Shanghai Med Coll, Shanghai 200032, Peoples R China
来源：
SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2020年 / 5卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1038/s41392-020-00218-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：3
相关论文
共 50 条
  • [21] Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling
    Zhang, Biqin
    Luk, Cheukyau
    Valadares, Joyce
    Aronis, Christos
    Foukas, Lazaros C.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (23)
  • [22] Src leads to a novel mechanism of resistance to PI3K inhibitors through regulation of PI3K/p85 activation
    Kim, Gui Chul
    Nam, Hae Yun
    Lee, Hyang Ju
    Kim, Min Kyung
    Lee, Geun Hee
    Han, Myung Woul
    Kim, Seong Who
    Kim, Sang Yoon
    [J]. CANCER RESEARCH, 2017, 77
  • [23] Regulation of the PI 3'-kinase catalytic subunit p110 by dimerization with the p85 regulatory subunit.
    Yu, JH
    McIlroy, J
    Wjasow, C
    Backer, JM
    [J]. DIABETES, 1997, 46 : 354 - 354
  • [24] Ligand-Selective Signal Transduction by Two Endogenous GnRH Isoforms Involves Biased Activation of the Class I PI3K Catalytic Subunits p110β, p110γ, and p110δ in Pituitary Gonadotropes and Somatotropes
    Pemberton, Joshua G.
    Stafford, James L.
    Chang, John P.
    [J]. ENDOCRINOLOGY, 2015, 156 (01) : 218 - 230
  • [25] Activating alterations of p110 subunits determine PI3K isoform selectivity in prostate cancer
    Zhang, Zeda
    Mao, Ninghui
    Lee, Young Sun
    Li, Dan
    Rosen, Neal
    Sawyers, Charles
    Carver, Brett
    [J]. MOLECULAR CANCER RESEARCH, 2020, 18 (10) : 39 - 40
  • [26] CoA Synthase is in complex with p85αPI3K and affects PI3K signaling pathway
    Breus, Oksana
    Panasyuk, Ganna
    Gout, Ivan T.
    Filonenko, Valeriy
    Nemazanyy, Ivan
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 385 (04) : 581 - 585
  • [27] The roles of D-3 and D-4-phosphorylated phosphoinositides produced by p85/p110 type PI-kinase
    Funaki, M
    Katagiri, H
    Ono, H
    Kikuchi, M
    Asano, T
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 85A - 85A
  • [28] Human tumor mutants in the p110α subunit of PI3K
    Liu, Zhenning
    Roberts, Thomas M.
    [J]. CELL CYCLE, 2006, 5 (07) : 675 - 677
  • [29] p110 δ PI3K as a therapeutic target of solid tumours
    Xenou, Lydia
    Papakonstanti, Evangelia A.
    [J]. CLINICAL SCIENCE, 2020, 134 (12): : 1377 - 1397
  • [30] The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis
    Utermark, Tamara
    Rao, Trisha
    Cheng, Hailing
    Wang, Qi
    Lee, Sang Hyun
    Wang, Zhigang C.
    Iglehart, J. Dirk
    Roberts, Thomas M.
    Muller, William J.
    Zhao, Jean J.
    [J]. GENES & DEVELOPMENT, 2012, 26 (14) : 1573 - 1586
12345