Palladium catalyzed direct α-arylation of α,α-difluoroketones with aryl bromides

被引：53
|
作者：
Guo, Chen [1 ]
Wang, Ruo-Wen [1 ]
Qing, Feng-Ling [1 ,2 ]
机构：
[1] Chinese Acad Sci, Key Lab Organofluorine Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2012年 / 143卷
基金：
中国国家自然科学基金;
关键词：
Direct arylation; Difluoroketones; Palladium-catalyzed reaction; ELECTROPHILIC FLUORINATION; MEDICINAL CHEMISTRY; REDUCTIVE ELIMINATION; KETONES; DIFLUORINATION; ROUTE; TRIFLUORIDE; F-TEDA-BF4; STRATEGIES; HALIDES;
D O I：
10.1016/j.jfluchem.2012.05.001
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The palladium-catalyzed direct alpha-arylations of alpha,alpha-difluoroketones with diverse aryl bromides have been developed by using rac-BINAP as ligand and Cs2CO3 as a mild base in xylene. This method provides an efficient and straightforward access to a variety of alpha-aryl-alpha,alpha-difluoroketones with broad substrate scope. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：135 / 142
页数：8
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