New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

被引：30
|
作者：
Hu, Jiansen [1 ,2 ]
Li, Zheng [1 ,2 ]
Gao, Jieyu [1 ,3 ]
He, Hongtao [1 ,2 ]
Dai, Huanqin [1 ]
Xia, Xuekui [4 ]
Liu, Cuihua [1 ]
Zhang, Lixin [5 ]
Song, Fuhang [1 ]
机构：
[1] Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Anhui, Peoples R China
[4] Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Key Biosensor Lab Shandong Provinde, Jinan 250013, Shandong, Peoples R China
[5] East China Univ Sci Technol, State Key Lab Bioreactor Engn, Shanghai 200031, Peoples R China
来源：
MARINE DRUGS | 2019年 / 17卷 / 05期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
marine-derived fungus; Aspergillus versicolor; diketopiperazine; antibacterial; ENDOPHYTIC FUNGUS; ENDOLICHENIC FUNGUS; METABOLITES; DERIVATIVES; ANTHRAQUINONES; BREVIANAMIDES; ANTIOXIDANT;
D O I：
10.3390/md17050262
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Six new diketopiperazines, (+/-)-7,8-epoxy-brevianamide Q ((+/-)-1), (+/-)-8-hydroxy-brevianamide R ((+/-)-2), and (+/-)-8-epihydroxy-brevianamide R ((+/-)-3), together with four known compounds, (+/-)-brevianamide R ((+/-)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. 1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guerin. Compounds 1-4 showed no activities against the pathogens, and compounds 5 and 6 showed moderate activities against S. aureus and methicillin-resistant S. aureus.
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页数：9
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