Multinuclear Anticancer Platinum Complexes

被引：0
|
作者：
Xu Gang [1 ,2 ]
Jiang Pingyuan [1 ,2 ]
Gou Shaohua [1 ,2 ]
机构：
[1] Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China
[2] Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Jiangsu, Peoples R China
来源：
PROGRESS IN CHEMISTRY | 2012年 / 24卷 / 09期
关键词：
multinuclear platinum complexes; anticancer activity; linking ligand; anticancer mechanism; DNA adduct; BREAST-CANCER CELLS; DNA-BINDING; IN-VITRO; CYTOTOXIC ACTIVITY; ANTITUMOR-ACTIVITY; PT(II) COMPLEXES; CISPLATIN RESISTANCE; DINUCLEAR PD(II); LIGANDS; DESIGN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Multinuclear platinum anticancer complexes have been investigated intensively due to their novel structures and promising anticancer activities. Moreover, they are able to overcome cisplatin resistance because of their abilities to form different adducts with DNA compared with those formed by cisplatin. The research status of dinuclear and multinuclear anticancer platinum complexes is reviewed. Based on the different linking ligands, dinuclear and multinuclear are divided to six types, namely, alkyl diamines and their derivatives, heterocyclic compounds containing nitrogen atom(s), carboxylates, haloid anions, ligands containing sulfur atom(s) and other ligands. The possible anticancer mechanism and structure-activity relationship of these multinuclear platinum complexes are also discussed in this paper.
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页码：1707 / 1719
页数：13
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