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- [23] High nuclear p27kip1 levels predicts sensitivity to neoadjuvant letrozole in ER plus breast cancer independent of pAKT levels, PIK3CA mutation status and cell cycle effects:: a potential role for p27kip1 in predicting enhanced autophagocytosis in response to aromatase inhibitor therapy. [J]. BREAST CANCER RESEARCH AND TREATMENT, 2006, 100 : S187 - S187