The chronergy of recombinant streptokinase thrombolysis in acute myocardial infarction

被引：4
|
作者：
Wang, Zhong-Ming [1 ]
Liu, Ya-Bing [2 ]
Jin, Qi-Chen [2 ]
Wang, Xue-Qi [3 ]
Dai, Meng [1 ]
Shao, Hui [4 ]
Zhao, Wen-Ping [5 ]
Dong, Qiu-Li [1 ]
Wang, Shu-Ping [6 ]
Zhang, Hai-Tao [1 ]
Kong, Li-Cha [1 ]
Liu, Shao-Yun [1 ]
Wang, Dong-Ying [1 ]
机构：
[1] North China Petr Adm, Gen Hosp, Dept Cardiol 2, Renqiu 062552, Hebei, Peoples R China
[2] North China Petr Adm, Jingxia Hosp, Dept Internal Med, Renqiu 062552, Hebei, Peoples R China
[3] Cent S Univ, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China
[4] North China Petr Adm, Jingxia Hosp, Dept Sci & Technol, Renqiu 062552, Hebei, Peoples R China
[5] Hebei Univ, Dept Cardiol, Affiliated Hosp, Baoding 071000, Hebei, Peoples R China
[6] North China Petr Adm, Jingxia Hosp, Dept Radiol, Renqiu 062552, Hebei, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2013年 / 5卷 / 05期
关键词：
acute myocardial infarction; chronergy of onset; thrombolytic therapy; morning resistance to thrombolysis; CORONARY-ARTERY-DISEASE; CIRCADIAN VARIATION; RISK STRATIFICATION; ISCHEMIA; INTERVENTION; FIBRINOLYSIS; HYPERTENSION; ANGIOPLASTY; EFFICACY; INSIGHTS;
D O I：
10.3892/etm.2013.980
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The aim of this study was to explore the chronergy of intravenous recombinant streptokinase (r-SK) in patients with acute myocardial infarction (AMI). A total of 114 patients were divided into two groups according to the time of AMI onset: the morning onset (6:01-12:00, n=53) and non-morning onset (12:01-06:00, n=61) groups. The recanalization rate was recorded, as well as anticoagulant and fibrinolytic indices. Statistical analysis was performed to evaluate the recanalization rate following thrombolysis, as well as the anticoagulant and fibrinolytic activities. The recanalization rates following thrombolysis in the morning onset and non-morning onset groups were 60.4 and 82.0%, respectively (P<0.05). The level of plasminogen activator inhibitor-1 (PAI-1) antigen was significantly higher in the morning onset group compared with. that in the non-morning onset group (P<0.05). This indicated a resistance to r-SK thrombolysis in the morning at the early stage of AMI, which possibly correlates with increased PAI-1 antigen levels and activity.
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页码：1363 / 1366
页数：4
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