Inhibition of AKT/mTOR signaling pathway induces cell cycle arrest and apoptosis in acute myelogenous leukemia.

被引:3
|
作者
Chen, WN [1 ]
Grammatikakis, I [1 ]
Li, J [1 ]
Leventaki, V [1 ]
Medeiros, LJ [1 ]
Rassidakis, GZ [1 ]
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
关键词
D O I
10.1182/blood.V106.11.2355.2355
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2355
引用
收藏
页码:663A / 663A
页数:1
相关论文
共 50 条
  • [1] Inhibition of AKT/mTOR signaling induces cell cycle arrest and apoptosis in mantle cell lymphoma.
    Peponi, E
    Drakos, E
    Reyes, G
    Leventaki, V
    Medeiros, LJ
    Rassidakis, GZ
    [J]. BLOOD, 2005, 106 (11) : 679A - 679A
  • [2] Apoptosis and Cell Cycle Arrest in Acute Myeloid Leukemia (AML) Induced by Metformin through Inhibition of the PI3K/AKT/mTOR Pathway
    Hou, Dongmei
    Ding, Qiang
    Li, Ruiqi
    Zhang, Yuan
    Zi, Fuming
    [J]. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2023, 37 (01): : 197 - 206
  • [3] Enzastaurin Induces Apoptosis and Cell Cycle Arrest in B-Cell Acute Lymphoblastic Leukemia Cell Lines Through AKT Pathway Inhibition and β-Catenin Accumulation
    Saba, Nakhle
    Angelova, Magdalena
    Lobelle-Rich, Patricia
    Levy, Laura S.
    [J]. BLOOD, 2012, 120 (21)
  • [4] Selenite Induces Cell Cycle Arrest and Apoptosis via Reactive Oxygen Species-Dependent Inhibition of the AKT/mTOR Pathway in Thyroid Cancer
    Cheng, Zhen
    Yu, Shuang
    He, Weiman
    Li, Jie
    Xu, Tianyi
    Xue, Junyu
    Shi, Peijie
    Chen, Shuwei
    Li, Yanbing
    Hong, Shubin
    Xiao, Haipeng
    [J]. FRONTIERS IN ONCOLOGY, 2021, 11
  • [5] Monensin-mediated growth inhibition in acute myelogenous leukemia cells via cell cycle arrest and apoptosis
    Park, WH
    Lee, MS
    Park, K
    Kim, ES
    Kim, BK
    Lee, YY
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2002, 101 (03) : 235 - 242
  • [6] The novel Akt inhibitor perifosine induces apoptosis, cell cycle arrest and synergizes with chemotherapeutic drugs in acute myelogenous leukemia cells by a JNK dependent mechanism - A novel therapeutic approach for leukemia displaying elevated Akt signaling
    Martelli, Alberto M.
    Papa, Veronica
    Tazzari, Pier Luigi
    Chiarini, Francesca
    Cappillini, Alessandra
    Ricci, Francesca
    Billi, Anna Maria
    Evangelisti, Camilla
    Abrams, Steve L.
    Ottaviani, Emanuela
    Martinelli, Giovanni
    McCubrey, James A.
    [J]. BLOOD, 2007, 110 (11) : 984A - 984A
  • [7] Analysis of the PI3/Akt/Survivin Pathway in Acute Myelogenous Leukemia.
    Serrano, Josefina
    Serrano-Lopez, Juana
    Sanchez Garcia, Joaquin
    Herrera, Concepcion
    Torres Gomez, Antonio P.
    [J]. BLOOD, 2009, 114 (22) : 1037 - 1038
  • [8] Sulforaphane Induces Cell Cycle Arrest and Apoptosis in Acute Lymphoblastic Leukemia Cells
    Suppipat, Koramit
    Park, Chun Shik
    Shen, Ye
    Zhu, Xiao
    Lacorazza, H. Daniel
    [J]. PLOS ONE, 2012, 7 (12):
  • [9] Matrine induces apoptosis in acute myeloid leukemia cells by inhibiting the PI3K/Akt/mTOR signaling pathway
    Hao, Yanmei
    Zhang, Nan
    Wei, Nannan
    Yin, Hongmei
    Zhang, Yingjie
    Xu, Hui
    Zhu, Chaomang
    Li, Duojie
    [J]. ONCOLOGY LETTERS, 2019, 18 (03) : 2891 - 2896
  • [10] Dentatin Induces Apoptosis and Cell Cycle Arrest of Acute Myeloid Leukemia Cells
    Wen, Li
    Liang, Yuli
    Li, Jing
    Quan, Meijie
    Li, Yanxiao
    Wang, Li
    [J]. CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, 2021, 19 (01) : 52 - 57