Efficient Synthesis of 6-Aryl-2-chloronicotinic Acids via Pd Catalyzed Regioselective Suzuki Coupling of 2,6-Dichloronicotinic Acid

被引：6
|
作者：
Ma, Mingliang [1 ]
Li, Chengwei [1 ]
Li, Xiaoyan [1 ]
Wen, Ke [1 ]
Liu, Yahu A. [2 ]
机构：
[1] E China Normal Univ, Key Lab Brain Funct Genom, MOE & STCSM, Shanghai Inst Brain Funct Genom, Shanghai 200062, Peoples R China
[2] ChemBridge Res Labs Inc, Med Chem, San Diego, CA 92127 USA
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2008年 / 45卷 / 06期
关键词：
D O I：
10.1002/jhet.5570450646
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A regioselective Suzuki coupling of 2,6-dichloronicotinic acid with aryl boronic acids to synthesize 6-aryl-2-chloronicotinic acids is described. Regioselectivity was achieved in aqueous dioxane using the routinely used catalyst Pd(PPh3)(4).
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页码：1847 / 1849
页数：3
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