Efficient Synthesis of 6-Aryl-2-chloronicotinic Acids via Pd Catalyzed Regioselective Suzuki Coupling of 2,6-Dichloronicotinic Acid

被引：6

作者：

Ma, Mingliang ^{[1
]}

Li, Chengwei ^{[1
]}

Li, Xiaoyan ^{[1
]}

Wen, Ke ^{[1
]}

Liu, Yahu A. ^{[2
]}

机构：

[1] E China Normal Univ, Key Lab Brain Funct Genom, MOE & STCSM, Shanghai Inst Brain Funct Genom, Shanghai 200062, Peoples R China

[2] ChemBridge Res Labs Inc, Med Chem, San Diego, CA 92127 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2008年 / 45卷 / 06期

关键词：

D O I：

10.1002/jhet.5570450646

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regioselective Suzuki coupling of 2,6-dichloronicotinic acid with aryl boronic acids to synthesize 6-aryl-2-chloronicotinic acids is described. Regioselectivity was achieved in aqueous dioxane using the routinely used catalyst Pd(PPh3)(4).

引用

页码：1847 / 1849

页数：3

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