The role of Toll-like receptors in immune disorders

被引：38
|
作者：
Uematsu, S
Akira, S
机构：
[1] Osaka Univ, Dept Host Def, Res Inst Microbial Dis, Suita, Osaka 5650851, Japan
[2] ERATO, Japan Sci & Technol Corp, Suita, Osaka 5650871, Japan
来源：
EXPERT OPINION ON BIOLOGICAL THERAPY | 2006年 / 6卷 / 03期
关键词：
autoimmune disease; polymorphism; Toll-like receptor;
D O I：
10.1517/14712598.6.3.203
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Toll-like receptors (TLRs) play an important role in innate immunity. Individual TLRs recognise microbial components that are conserved among pathogens. Such recognition initiates necessary inflammatory immune responses and induces subsequent activation of adaptive immunity. Studies in people with polymorphisms in genes encoding TLR signalling can elucidate the relationship between TLRs and human diseases, such as infectious diseases, atherosclerosis and immunodeficiency. Indeed, accumulating data in respect to TLR signalling suggest that TLRs are closely related with the pathogenesis of autoimmune diseases. This review looks at the role of TLRs in various immune disorders, and discusses the pathogenesis of diseases.
引用
收藏
页码：203 / 214
页数：12
相关论文
共 50 条
  • [21] Inflammation and pregnancy - The role of toll-like receptors in trophoblast-immune interaction
    Mor, Gil
    [J]. ASSESSMENT OF HUMAN REPRODUCTIVE FUNCTION, 2008, 1127 : 121 - 128
  • [22] The role of toll-like receptors in immune tolerance induced by Helicobacter pylori infection
    Zhang, Xiulin
    Zhang, Ke
    Yan, Linlin
    Wang, Pengfei
    Zhao, Fan
    Hu, Shoukui
    [J]. HELICOBACTER, 2023, 28 (06)
  • [23] The role of Toll-like receptors and MyD88 in innate immune responses
    Akira, S
    Hoshino, K
    Kaisho, T
    [J]. JOURNAL OF ENDOTOXIN RESEARCH, 2000, 6 (05): : 383 - 387
  • [24] Paradoxical immune response in leishmaniasis: The role of toll-like receptors in disease progression
    Bamigbola, Ifeoluwa E.
    Ali, Selman
    [J]. PARASITE IMMUNOLOGY, 2022, 44 (4-5)
  • [25] The role of Toll-like receptors in rheumatoid arthritis
    Pope R.M.
    Huang Q.-Q.
    [J]. Current Rheumatology Reports, 2009, 11 (5) : 357 - 364
  • [26] Toll-Like Receptors and their Role in Hematologic Malignancies
    Wolska, Anna
    Lech-Maranda, Ewa
    Robak, Tadeusz
    [J]. CURRENT MOLECULAR MEDICINE, 2009, 9 (03) : 324 - 335
  • [27] The role of Toll-like receptors in the pathogenesis of EAE
    Hansen, B
    Lovett-Racke, AE
    Hussain, RZ
    Northrop, SC
    Racke, MK
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2004, 154 (1-2) : 57 - 57
  • [28] Role of toll-like receptors in systemic sclerosis
    Ciechomska, Marzena
    Cant, Rachel
    Finnigan, James
    van Laar, Jacob M.
    O'Reilly, Steven
    [J]. EXPERT REVIEWS IN MOLECULAR MEDICINE, 2013, 15
  • [29] The role of Toll-like receptors in chronic inflammation
    Drexler, Stefan K.
    Foxwell, Brian M.
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (04): : 506 - 518
  • [30] Role of toll-like receptors in multiple sclerosis
    Miranda-Hernandez, Socorro
    Baxter, Alan G.
    [J]. AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2013, 2 (01) : 75 - 93
12345