The role of Toll-like receptors in immune disorders

被引：38
|
作者：
Uematsu, S
Akira, S
机构：
[1] Osaka Univ, Dept Host Def, Res Inst Microbial Dis, Suita, Osaka 5650851, Japan
[2] ERATO, Japan Sci & Technol Corp, Suita, Osaka 5650871, Japan
来源：
EXPERT OPINION ON BIOLOGICAL THERAPY | 2006年 / 6卷 / 03期
关键词：
autoimmune disease; polymorphism; Toll-like receptor;
D O I：
10.1517/14712598.6.3.203
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Toll-like receptors (TLRs) play an important role in innate immunity. Individual TLRs recognise microbial components that are conserved among pathogens. Such recognition initiates necessary inflammatory immune responses and induces subsequent activation of adaptive immunity. Studies in people with polymorphisms in genes encoding TLR signalling can elucidate the relationship between TLRs and human diseases, such as infectious diseases, atherosclerosis and immunodeficiency. Indeed, accumulating data in respect to TLR signalling suggest that TLRs are closely related with the pathogenesis of autoimmune diseases. This review looks at the role of TLRs in various immune disorders, and discusses the pathogenesis of diseases.
引用
收藏
页码：203 / 214
页数：12
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