canSAR: update to the cancer translational research and drug discovery knowledgebase

被引：37

作者：

Coker, Elizabeth A. ^{[1
,3
]}

Mitsopoulos, Costas ^{[2
]}

Tym, Joesph E. ^{[1
]}

Komianou, Angeliki ^{[1
]}

Kannas, Christos ^{[1
]}

Di Micco, Patrizio ^{[1
]}

Fernandez, Eloy Villasclaras ^{[1
]}

Ozer, Bugra ^{[1
,2
]}

Antolin, Albert A. ^{[1
]}

Workman, Paul ^{[2
]}

Al-Lazikani, Bissan ^{[1
,2
]}

机构：

[1] Inst Canc Res, Dept Data Sci, London SM2 5NG, England

[2] Inst Canc Res, Canc Res UK Canc Therapeut Unit, London SM2 5NG, England

[3] Wellcome Trust Sanger Inst, Translat Canc Genom, Hinxton, England

来源：

NUCLEIC ACIDS RESEARCH | 2019年 / 47卷 / D1期

关键词：

D O I：

10.1093/nar/gky1129

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs researchers to help solve key bottlenecks in cancer translation and drug discovery. It integrates genomic, protein, pharmacological, drug and chemical data with structural biology, protein networks and unique, comprehensive and orthogonal druggability' assessments. canSAR is widely used internationally by academia and industry. Here we describe major enhancements to canSAR including new and expanded data. We also describe the first components of canSARblackan advanced, responsive, multi-device compatible redesign of canSAR with a question-led interface.

引用

页码：D917 / D922

页数：6

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