Enhanced antitumor activity of the HIF-1 inhibitor PX-478 combined with radiation and chemotherapy in pancreatic cancer

被引:0
|
作者
Powis, Garth
Von Hoff, Daniel
Bankson, James
Lemos, Robert
Hostetter, Galen
Demeure, Michael
Schwartz, David
机构
关键词
D O I
10.1158/1535-7163.TARG-09-B194
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B194
引用
收藏
页数:3
相关论文
共 50 条
  • [41] Hypomethylation at non-CpG/CpG sites in the promoter of HIF-1α gene combined with enhanced H3K9Ac modification contribute to maintain higher HIF-1α expression in breast cancer
    Li, Chun
    Xiong, Wei
    Liu, Xiong
    Xiao, Wenjun
    Guo, Yuxian
    Tan, Junyu
    Li, Yaochen
    ONCOGENESIS, 2019, 8 (4)
  • [42] Correction: Corrigendum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels
    Hiroshi Harada
    Masahiro Inoue
    Satoshi Itasaka
    Kiichi Hirota
    Akiyo Morinibu
    Kazumi Shinomiya
    Lihua Zeng
    Guangfei Ou
    Yuxi Zhu
    Michio Yoshimura
    W. Gillies Mckenna
    Ruth J. Muschel
    Masahiro Hiraoka
    Nature Communications, 4
  • [43] The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1α Activity by Changing miR Expression Patterns in Human Cancer Cells
    Bertozzi, Davide
    Marinello, Jessica
    Manzo, Stefano G.
    Fornari, Francesca
    Gramantieri, Laura
    Capranico, Giovanni
    MOLECULAR CANCER THERAPEUTICS, 2014, 13 (01) : 239 - 248
  • [44] Hypoxia regulates ABCG2 activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells
    He, Xiaodan
    Wang, Juan
    Wei, Wei
    Shi, Meiyan
    Xin, Beibei
    Zhang, Ti
    Shen, Xiaohong
    CANCER BIOLOGY & THERAPY, 2016, 17 (02) : 188 - 198
  • [45] Combined Treatment of Pancreatic Cancer with Mithramycin A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity
    Chou, Ting-Chao
    CANCER RESEARCH, 2011, 71 (07) : 2793 - 2793
  • [46] Combined Treatment of Pancreatic Cancer with Mithramycin A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity
    Jia, Zhiliang
    Gao, Yong
    Wang, Liwei
    Li, Qiang
    Zhang, Jun
    Le, Xiangdong
    Wei, Daoyan
    Yao, James C.
    Chang, David Z.
    Huang, Suyun
    Xie, Keping
    CANCER RESEARCH, 2010, 70 (03) : 1111 - 1119
  • [47] Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer
    Kelie M Reece
    Emily D Richardson
    Kristina M Cook
    Tessa J Campbell
    Stephen T Pisle
    Alesia J Holly
    David J Venzon
    David J Liewehr
    Cindy H Chau
    Douglas K Price
    William D Figg
    Molecular Cancer, 13
  • [48] Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer
    Reece, Kelie M.
    Richardson, Emily D.
    Cook, Kristina M.
    Campbell, Tessa J.
    Pisle, Stephen T.
    Holly, Alesia J.
    Venzon, David J.
    Liewehr, David J.
    Chau, Cindy H.
    Price, Douglas K.
    Figg, William D.
    MOLECULAR CANCER, 2014, 13
  • [49] Novel cFlip inhibitor suppresses chemotherapy-induced breast cancer stem cell activity through blocking HIF1-α
    Robinson, Tim
    Turnham, Dan
    Gruca, Aleks
    Piggott, Luke
    Clarkson, Richard
    CANCER RESEARCH, 2018, 78 (04)
  • [50] Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels (vol 3, pg 783, 2013)
    Harada, Hiroshi
    Inoue, Masahiro
    Itasaka, Satoshi
    Hirota, Kiichi
    Morinibu, Akiyo
    Shinomiya, Kazumi
    Zeng, Lihua
    Ou, Guangfei
    Zhu, Yuxi
    Yoshimura, Michio
    Mckenna, W. Gillies
    Muschel, Ruth J.
    Hiraoka, Masahiro
    NATURE COMMUNICATIONS, 2013, 4