Enhanced antitumor activity of the HIF-1 inhibitor PX-478 combined with radiation and chemotherapy in pancreatic cancer

被引:0
|
作者
Powis, Garth
Von Hoff, Daniel
Bankson, James
Lemos, Robert
Hostetter, Galen
Demeure, Michael
Schwartz, David
机构
关键词
D O I
10.1158/1535-7163.TARG-09-B194
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B194
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in Pancreatic Cancer
    Schwartz, David L.
    Bankson, James A.
    Lemos, Robert, Jr.
    Lai, Stephen Y.
    Thittai, Arun K.
    He, Yi
    Hostetter, Galen
    Demeure, Michael J.
    Von Hoff, Daniel D.
    Powis, Garth
    [J]. MOLECULAR CANCER THERAPEUTICS, 2010, 9 (07) : 2057 - 2067
  • [2] A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor
    Kyeong Lee
    Hwan Mook Kim
    [J]. Archives of Pharmacal Research, 2011, 34 : 1583 - 1585
  • [3] PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer
    Meymandi, Ahmad Reza Panahi
    Akbari, Behnia
    Soltantoyeh, Tahereh
    Shahosseini, Zahra
    Hosseini, Mina
    Hadjati, Jamshid
    Mirzaei, Hamid Reza
    [J]. FRONTIERS IN ONCOLOGY, 2024, 14
  • [4] A Novel Approach to Cancer Therapy using PX-478 as a HIF-1α Inhibitor
    Lee, Kyeong
    Kim, Hwan Mook
    [J]. ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (10) : 1583 - 1585
  • [5] HIF-1α inhibitor PX-478 preserves pancreatic. cell function in diabetes
    Ilegems, Erwin
    Bryzgalova, Galyna
    Correia, Jorge
    Yesildag, Burcak
    Berra, Edurne
    Ruas, Jorge L.
    Pereira, Teresa S.
    Berggren, Per-Olof
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2022, 14 (638)
  • [6] PX-478, a potent inhibitor of hypoxia-inducible factor-1 (HIF-1) and antitumor agent
    Welsh, SJ
    Williams, RR
    Kirkpatrick, DL
    Powis, G
    [J]. EUROPEAN JOURNAL OF CANCER, 2002, 38 : S90 - S90
  • [7] HIF-1α as a cancer drug target:: Its inhibition and antitumor activity by PX-478.
    Powis, G
    Welsh, SJ
    Kirkpatrick, LD
    [J]. CLINICAL CANCER RESEARCH, 2003, 9 (16) : 6273S - 6273S
  • [8] The molecular mechanisms for the activity of PX-478, an antitumor inhibitor of hypoxia-inducible factor 1α
    Koh, Mei Yee
    Spivak-Kroizman, Taly
    Venturini, Sara
    Welsh, Sarah J.
    Williams, Ryan R.
    Powis, Garth
    [J]. MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3428S - 3428S
  • [9] Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α
    Welsh, S
    Williams, R
    Kirkpatrick, L
    Paine-Murrieta, G
    Powis, G
    [J]. MOLECULAR CANCER THERAPEUTICS, 2004, 3 (03) : 233 - 244
  • [10] Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α
    Koh, Mei Y.
    Spivak-Kroizman, Taly
    Venturini, Sara
    Welsh, Sarah
    Williams, Ryan R.
    Kirkpatrick, D. Lynn
    Powis, Garth
    [J]. MOLECULAR CANCER THERAPEUTICS, 2008, 7 (01) : 90 - 100