Oral Treatment With Pbi-4050 Reduces Plasminogen Activator Inhibitor-1 (pai-1), Alpha-Smooth Muscle Actin (α-Sma) and Collagen Expression In Human Fibroblasts And Mice Fibrotic Lungs

被引:0
|
作者
Gagnon, L. [1 ]
Leduc, M. [1 ]
Grouix, B. [1 ]
Tremblay, M. [1 ]
Sarra-Bournet, F. [1 ]
Laverdure, A. [1 ]
Gagnon, W. [1 ]
Geerts, L. [1 ]
Hince, K. [1 ]
Gervais, L. [1 ]
Cloutier, M. -P. [1 ]
Abbott, S. [1 ]
Duceppe, J. -S. [1 ]
Zacharie, B. [1 ]
Laurin, P. [1 ]
机构
[1] ProMet BioSci Inc, Laval, PQ, Canada
关键词
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
A5936
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices
    Garg, N.
    Goyal, N.
    Strawn, T. L.
    Wu, J.
    Mann, K. M.
    Lawrence, D. A.
    Fay, W. P.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (08) : 1847 - 1854
  • [42] REGULATION OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) EXPRESSION IN HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS (HUVEC) - INDUCTION OF PROMOTER REPORTER GENE-EXPRESSION WITH PHORBOLESTERS
    DESCHEEMAEKER, RA
    NELLES, L
    MOREAU, H
    VANCOETSEM, T
    WYNS, S
    COLLEN, D
    [J]. THROMBOSIS AND HAEMOSTASIS, 1991, 65 (06) : 807 - 807
  • [43] ACTIVATED HUMAN PROTEIN-C (APC) REDUCES THE PLASMA-LEVELS OF TYPE-1 PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1) ACTIVITY IN MICE
    COLUCCI, M
    MOMI, S
    NASIMI, M
    NENCI, GG
    SEMERARO, N
    GRESELE, P
    [J]. THROMBOSIS AND HAEMOSTASIS, 1995, 73 (06) : 1253 - 1253
  • [44] INHIBITION OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) GENE-EXPRESSION BY INTERFERON-ALPHA AND INTERFERON-GAMMA IN CULTURED HUMAN RETINAL-PIGMENT EPITHELIAL-CELLS
    SIREN, V
    IMMONEN, I
    VAHERI, A
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1993, 34 (04) : 871 - 871
  • [45] Hypoxia and cytokines differentially regulate the expression of the tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) genes in cultured human mesothelial cells (HMCs): Implications for post-surgical peritoneal fibrinolytic dysregulation
    Keenan, Benjamin J.
    Currie, Brian M.
    Heydrick, Stanley J.
    Stucchi, Arthur F.
    [J]. FASEB JOURNAL, 2013, 27
  • [46] Vitamin D receptor activators modulate the expression of thrombomodulin, thrombospondin and plasminogen activator inhibitor-1 in human coronary artery smooth muscle cells
    Wu-Wong, JR
    Nakane, M
    Ma, JL
    [J]. FASEB JOURNAL, 2006, 20 (05): : A1111 - A1111
  • [47] Combined effect of glucose and insulin in stimulating plasminogen activator inhibitor-1 secretion and gene expression in human vascular smooth muscle cells in culture
    Pandolfi, A
    Di Febbo, C
    Baccante, G
    Alberta, MM
    Capani, F
    Vitacolonna, E
    Porreca, E
    Consoli, A
    [J]. DIABETES NUTRITION & METABOLISM, 1997, 10 (05) : 219 - 224
  • [48] Transcription factor decoy ODN for activator protein-1 (AP-1) inhibits expression of type 1 plasminogen activator inhibitor (PAI-1) gene induced by high glucose and angiotensin II in cultured human vascular smooth muscle cells
    Lee, IK
    Ahn, JD
    Lee, SJ
    Lee, DW
    Kang, HK
    [J]. DIABETES, 2001, 50 : A246 - A246
  • [49] Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth muscle cells
    Ahn, JD
    Morishita, R
    Kaneda, Y
    Lee, KU
    Park, JY
    Jeon, YJ
    Song, HS
    Lee, IK
    [J]. DIABETOLOGIA, 2001, 44 (06) : 713 - 720
  • [50] Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblasts
    Asokananthan, Nithiananthan
    Lan, Rommel S.
    Graham, Peter T.
    Bakker, Anthony J.
    Tokanovic, Ana
    Stewart, Geoffrey A.
    [J]. PHYSIOLOGICAL REPORTS, 2015, 3 (02):