Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase

被引：16
|
作者：
Montgomery, Justin I. [1 ]
Toogood, Peter L. [1 ]
Hutchings, Kim M. [1 ]
Liu, Jia [1 ]
Narasimhan, Lakshmi [1 ]
Braden, Timothy [1 ]
Dermyer, Michael R. [1 ]
Kulynych, Angela D. [1 ]
Smith, Yvonne D. [1 ]
Warmus, Joseph S. [1 ]
Taylor, Clarke [1 ]
机构：
[1] Pfizer Global Res & Dev, Michigan Labs, Ann Arbor, MI 48105 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期
关键词：
Phenylalanyl-tRNA synthetase; PheRS; FRS; Aminoacyl-tRNA synthetase; Benzyl phenyl ether; Antibacterial; SAR; POTENT; SERIES; AGENTS;
D O I：
10.1016/j.bmcl.2008.12.054
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of benzyl phenyl ethers (BPEs) is described that displays potent inhibition of bacterial phenylalanyl-tRNA synthetase. The synthesis, SAR, and select ADMET data are provided. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：665 / 669
页数：5
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