Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Leprfa (SDT Fatty) Rats

被引：15
|
作者：
Yamaguchi, Takayuki [1 ]
Sasase, Tomohiko [1 ]
Mera, Yasuko [1 ]
Tomimoto, Daisuke [1 ]
Tadaki, Hironobu [1 ]
Kemmochi, Yusuke [2 ]
Ohta, Takeshi [1 ]
Sato, Eimei [3 ]
Matsushita, Mutsuyoshi [1 ]
机构：
[1] Japan Tobacco Inc, Biol Pharmacol Res Labs, Cent Pharmaceut Res Inst, Takatsuki, Osaka 5691125, Japan
[2] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Toxicol Res Labs, Hadano, Kanagawa 2570024, Japan
[3] Tohoku Univ, Lab Anim Reprod, Grad Sch Agr Sci, Fac Agr,Aoba Ku, Sendai, Miyagi 9818555, Japan
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2012年 / 74卷 / 12期
关键词：
diabetes; diabetic peripheral neuropathy; nerve conduction velocity; SDT fatty rat; NERVE-CONDUCTION; INSULIN THERAPY; COMPLICATIONS; INHIBITOR; MELLITUS; TERM; PROGRESSION; PREVENTS; OBESITY; MODEL;
D O I：
10.1292/jvms.12-0149
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Spontaneously Diabetic Toni (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia is late. SDT fatty rat, established by introducing the fa allele of the Zucker fatty rat to SDT rat, develops diabetes much faster than SDT rat. In the present study, diabetic peripheral neuropathy (DPN) was evaluated to show the further usefulness of this animal model. Motor nerve conduction velocity (MNCV) was delayed, and the number of sural nerve fibers was decreased in SDT fatty rat. Treatment of pioglitazone lowered blood glucose level and prevented delay of MNCV in SDT fatty rats. SDT fatty rat is a useful animal model for studies of DPN in type 2 diabetes.
引用
收藏
页码：1669 / 1673
页数：5
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