Pediatric high-grade gliomas

被引：6
|
作者：
Kramm, C. [1 ,2 ]
Rausche, U. [1 ,2 ]
Butenhoff, S. [1 ,2 ]
Kuehnoel, C. [1 ,2 ]
Kunze, C. [3 ]
Kortmann, R. [4 ]
Wolff, J. [5 ]
van Gool, S. [6 ]
机构：
[1] Univ Klinikum Halle Saale, Univ Klin & Poliklin Kinder & Jugendmed, D-06120 Halle, Saale, Germany
[2] Univ Klinikum Halle Saale, HIT HGG Studienleitung, D-06120 Halle, Saale, Germany
[3] Univ Klinikum Halle Saale, Univ Klin & Poliklin Diagnost Radiol, D-06120 Halle, Saale, Germany
[4] Univ Leipzig, Klin Strahlentherapie & Radioonkol, Leipzig, Germany
[5] Univ Texas Houston, MD Anderson Canc Ctr, Dept Pediat, Houston, TX 77030 USA
[6] Univ Hosp Gasthuisberg, B-3000 Louvain, Belgium
来源：
MONATSSCHRIFT KINDERHEILKUNDE | 2008年 / 156卷 / 12期
关键词：
Children; Glioblastoma; Anaplastic astrocytoma; Pontine glioma; Immunotherapy;
D O I：
10.1007/s00112-008-1799-3
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Pediatric high-grade gliomas comprise different tumor entities of glial origin that are characterized by their malignant histopathologic phenotype or poor clinical course. Glioblastoma multiforme, anaplastic astrocytoma, and pontine glioma represent the most frequent pediatric high-grade gliomas. Current treatment recommendations include surgery, radiotherapy, and chemotherapy, with the exception of pontine gliomas, which are treated solely by radiotherapy and chemotherapy. Complete tumor resection still has the highest prognostic impact. Although overall survival is still poor for most patients, infants and very young children with high-grade gliomas show good overall survival with conventional chemotherapy and surgery. For these patients, a separate chemotherapy protocol is currently being developed in several European countries. For older patients, new multimodal treatment protocols containing innovative tumor-specific as well as conventional treatment strategies must be established.
引用
收藏
页码：1201 / 1207
页数：7
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