Critical Role for Histone Deacetylase 6 (HDAC6) in the Regulation of IL-6, and the JAK/STAT3 Signaling Cascade in Macrophages

被引:0
|
作者
Perez-Villarroel, P. [1 ]
Lienlaf, M. [1 ]
Cheng, F. [1 ]
Knox, T. [1 ]
Wang, H. [1 ]
Marante, D. [1 ]
Yoder, S. [2 ]
Woan, K. [1 ]
Canales, J. [1 ]
Pinilla-Ibarz, J. [3 ]
Seto, E. [4 ]
Sotomayor, E. [3 ]
Villagra, A. [1 ]
机构
[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Immunol, Tampa, FL 33612 USA
[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Mol Genom Core, Tampa, FL 33612 USA
[3] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Immunol & Malignant Hematol, Tampa, FL 33612 USA
[4] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Mol Oncol, Tampa, FL 33612 USA
关键词
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
1498
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Disruption of IL-6 signaling in the IL-6/JAK/STAT pathway using small molecules
    Fuchs, James R.
    Jena, Nivedita
    Kumari, Vandana
    Mok, May
    Li, Pui-Kai
    Li, Chenglong
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [22] Small Molecule Inhibitors of IL-6/STAT3 Signaling
    Ye Jiqing
    Yue Xiaohong
    Sun Liping
    [J]. PROGRESS IN CHEMISTRY, 2016, 28 (07) : 1099 - 1111
  • [23] Study on expression of IL-6/JAK/STAT3 signaling pathway in category IIIB prostatitis
    Li, Guangyu
    Lan, Haiyan
    Liang, Jihong
    Xian, Jing
    Fang, Dan
    Mo, Yuncong
    Zheng, Cheng
    Dong, Yingjin
    Li, Yuanfa
    [J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (04): : 3779 - 3785
  • [24] Development of the first small molecule histone deacetylase 6 (HDAC6) degraders
    Yang, Ka
    Song, Yanling
    Xie, Haibo
    Wu, Hao
    Wu, Yi-Ting
    Leisten, Eric D.
    Tang, Weiping
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (14) : 2493 - 2497
  • [25] HDAC6 Deacetylase Activity Is Critical for Lipopolysaccharide-Induced Activation of Macrophages
    Yan, Bing
    Xie, Songbo
    Liu, Zhu
    Ran, Jie
    Li, Yuanyuan
    Wang, Jian
    Yang, Yang
    Zhou, Jun
    Li, Dengwen
    Liu, Min
    [J]. PLOS ONE, 2014, 9 (10):
  • [26] A Novel Role for Histone Deacetylase 6 (HDAC6) in the Regulation of IL-10 and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs).
    Cheng, Fengdong
    Wang, Hongwei
    Luetteke, Noreen
    Pinilla, Javier
    Kozikowski, Alan
    Seto, Edward
    Villagra, Alejandro V.
    Sotomayor, Eduardo
    [J]. BLOOD, 2009, 114 (22) : 554 - 555
  • [27] Epigenetic Modulation of STAT3 by Histone Deacetylase 6 (HDAC6) Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)
    Cheng, Fengdong
    Wang, Zi
    Wang, Hongwei
    Woan, Karrune V.
    Sahakian, Eva
    Klotz, Jennifer Rock
    Wang, Liqing
    Han, Rongxiang
    Merino, Oscar
    Deng, Susan
    Vazquez, Lianet
    Gill, Ajaypal S.
    Marante, Danay
    Powers, John
    Hancock, Wayne W.
    Pinilla, Javier
    Seto, Edward
    Sotomayor, Eduardo M.
    Villagra, Alejandro
    [J]. BLOOD, 2011, 118 (21) : 242 - 242
  • [28] Physical Interaction of Histone Deacetylase 6 (HDAC6) with STAT3 Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)
    Cheng, Fengdong
    Wang, Zi
    Wang, Hongwei
    Lienlaf, Maritza
    Woan, Karrune V.
    Perez-Villarroel, Patricio
    Rock-Klotz, Jennifer
    Sahakian, Eva
    Knox, Tessa
    Woods, David M.
    Powers, John
    Han, Rongxiang
    Merino, Oscar
    Deng, Susan
    Marante, Danay
    Hancock, Wayne W.
    Kozikowski, Alan
    Bergman, Joel
    Pinilla, Javier
    Seto, Edward
    Sotomayor, Eduardo M.
    Villagra, Alejandro
    [J]. BLOOD, 2012, 120 (21)
  • [29] Histone deacetylase-6 (HDAC6) modulates akt and STAT3 activity via heat shock protein (Hsp) 90 in human multiple myeloma
    Hideshima, Teru
    Bradner, James E.
    Yasui, Hiroshi
    Raje, Noopur
    Chauhan, Dharminder
    Podar, Klaus
    Tai, Yu-Tzu
    Mitsiades, Constantine
    Richardson, Paul G.
    Mazitschek, Ralph
    Schreiber, Stuart L.
    Anderson, Kenneth C.
    [J]. BLOOD, 2006, 108 (11) : 978A - 978A
  • [30] Inhibition of Histone Deacetylase 6 Activity Provides Protection Against Atherogenesis: a Role for HDAC6 NEDDylation
    Nomura, Yohei
    Rossberg, Max C.
    Bhatta, Anil
    Romer, Lew
    Berkowitz, Dan
    Pandey, Deepesh
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2018, 38