Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles

被引：18
|
作者：
Hojo, Keiko [1 ]
Shinozaki, Natsuki
Nozawa, Yoshimi
Fukumori, Yoshinobu
Ichikawa, Hideki
机构：
[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Chuo Ku, Kobe, Hyogo 6508586, Japan
来源：
APPLIED SCIENCES-BASEL | 2013年 / 3卷 / 03期
关键词：
aqueous synthesis; solid-phase peptide synthesis; microwave assisted synthesis; nanoparticles; Boc chemistry;
D O I：
10.3390/app3030614
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have previously developed water-based microwave (MW)-assisted peptide synthesis using Fmoc-amino acid nanopaticles. It is an organic solvent-free, environmentally friendly method for peptide synthesis. Here we describe water-based MW-assisted solid-phase synthesis using Boc-amino acid nanoparticles. The microwave irradiation allowed rapid solid-phase reaction of nanoparticle reactants on the resin in water. We also demonstrated the syntheses of Leu-enkephalin, Tyr-Gly-Gly-Phe-Leu-OH, and difficult sequence model peptide, Val-Ala-Val-Ala-Gly-OH, using our water-based MW-assisted protocol with Boc-amino acid nanoparticles.
引用
收藏
页码：614 / 623
页数：10
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