How to make a primordial germ cell

被引：93
|
作者：
Magnusdottir, Erna [1 ,2 ,3 ,4 ]
Surani, M. Azim [1 ,2 ,3 ]
机构：
[1] Univ Cambridge, Gurdon Inst, Canc Res UK, Wellcome Trust, Cambridge CB2 1QN, England
[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England
[3] Univ Cambridge, Stem Cell Inst, Wellcome Trust Med Res Council, Cambridge CB2 3DY, England
[4] Univ Iceland, Dept Biochem & Mol Biol, IS-101 Reykjavik, Iceland
来源：
DEVELOPMENT | 2014年 / 141卷 / 02期
基金：
英国惠康基金;
关键词：
Epigenetic programming; Primordial germ cells; Specification; Transcription factors; EMBRYONIC STEM-CELLS; DNA METHYLATION; MOUSE EMBRYO; HISTONE DEACETYLASE; NAIVE PLURIPOTENCY; GROUND-STATE; IN-VITRO; MICE; SPECIFICATION; GENOME;
D O I：
10.1242/dev.098269
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Primordial germ cells (PGCs) are the precursors of sperm and eggs, which generate a new organism that is capable of creating endless new generations through germ cells. PGCs are specified during early mammalian postimplantation development, and are uniquely programmed for transmission of genetic and epigenetic information to subsequent generations. In this Primer, we summarise the establishment of the fundamental principles of PGC specification during early development and discuss how it is now possible to make mouse PGCs from pluripotent embryonic stem cells, and indeed somatic cells if they are first rendered pluripotent in culture.
引用
收藏
页码：245 / 252
页数：8
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