Inner nuclear membrane protein transport is mediated by multiple mechanisms

被引:26
|
作者
Zuleger, Nikolaj [1 ]
Korfali, Nadia [1 ]
Schirmer, Eric C. [1 ]
机构
[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland
基金
英国惠康基金;
关键词
inner nuclear membrane (INM); lateral diffusion-retention; nuclear envelope (NE); nuclear localization signal (NLS); nuclear pore complex (NPC); nuclear transport;
D O I
10.1042/BST0361373
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
work in the nuclear transport field has led to an incredibly detailed description of protein translocation through the central channel of the nuclear pore complex, yet the mechanism by which nuclear envelope transmembrane proteins reach the inner nuclear membrane after synthesis in the endoplasmic reticulum is still hotly debated. Three different translocation models have gained experimental support: (i) simple lateral diffusion through the nuclear envelope membrane system; (ii) translocation by vesicle fusion events; and (iii) a variation on classical transport mediated by the nuclear pore complex. Although these models appear to be mutually exclusive, in the present paper we argue that they probably all function for different inner nuclear membrane proteins according to their unique characteristics.
引用
收藏
页码:1373 / 1377
页数:5
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