Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke

被引：19
|
作者：
Mourao, Aline Mansueto [1 ,2 ,3 ]
Caseiro Vicente, Laelia Cristina [3 ]
Silva Abreu, Mery Natali [4 ]
Sant'Anna, Romeu Vale [1 ]
Marciano Vieira, Erica Leandro [5 ]
de Souza, Leonardo Cruz [5 ]
de Miranda, Aline Silva [5 ]
Rachid, Milene Alvarenga [5 ]
Teixeira, Antonio Lucio [5 ]
机构：
[1] Univ Fed Minas Gerais, BR-31170220 Belo Horizonte, MG, Brazil
[2] Risoleta Tolentino Neves Hosp, Sect Stroke Unit, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Dept Speech Therapy, Belo Horizonte, MG, Brazil
[4] Univ Fed Minas Gerais, Dept Appl Nursing, Belo Horizonte, MG, Brazil
[5] Univ Minas Gerais UFMG, Sch Med, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil
来源：
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2019年 / 28卷 / 03期
关键词：
Brain-derived neurotrophic factor; biomarker; stroke; ichemic stroke; stroke outcome; prognosis; BDNF; BIOMARKERS; BLOOD; GROWTH;
D O I：
10.1016/j.jstrokecerebrovasdis.2018.11.013
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke.
引用
收藏
页码：735 / 740
页数：6
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