Stereocontrolled total synthesis of pancratistatin

被引：75
|
作者：
Kim, S
Ko, H
Kim, E
Kim, D
机构：
[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 08期
关键词：
D O I：
10.1021/ol0256419
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A new total synthesis of the antitumor alkaloids, pancratistatin (1), has been accomplished from readily available staring materials. The Claisen rearrangement of dihydropyranethylene 5 was employed to construct the A and C rings. Stereo- and regiocontrolled functional group interchange, such as iodolactonization, dihydroxylations, and a cyclic sulfate elimination reaction, allows for the production of the target natural product.
引用
收藏
页码：1343 / 1345
页数：3
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