Poxvirus preparation CONPIND initiates production of the major inflammatory mediators IL-1 alpha and TNF-alpha in human whole blood and in blood mononuclear cell cultures

被引：6
|
作者：
Ahne, W
Mayr, A
机构：
[1] Veterinary Faculty, University of Munich, D-80539, Munich
来源：
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 1997年 / 20卷 / 02期
关键词：
poxvirus; paramunity inducer; CONPIND; interleukin; 1; alpha; tumour necrosis factor alpha; human whole blood; human blood mononuclear cell culture;
D O I：
10.1016/S0147-9571(96)00040-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The poxvirus preparation CONPIND initiated the production of the two major inflammatory mediators interleukin-1 alpha (IL-1 alpha) and tumour necrosis factor-alpha (TNF-alpha) in whole blood and in blood mononuclear cell cultures of man at 37 degrees C within 12-48 h. The release of the cytokines followed a dose-efficacy curve. High levels of IL1-alpha (up to 810 pg/ml) and TNF-alpha (up to 533 pg/ml) were determined by sandwich enzyme-linked immunosorbent assay.
引用
收藏
页码：139 / 145
页数：7
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