Poxvirus preparation CONPIND initiates production of the major inflammatory mediators IL-1 alpha and TNF-alpha in human whole blood and in blood mononuclear cell cultures

被引：6
|
作者：
Ahne, W
Mayr, A
机构：
[1] Veterinary Faculty, University of Munich, D-80539, Munich
来源：
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 1997年 / 20卷 / 02期
关键词：
poxvirus; paramunity inducer; CONPIND; interleukin; 1; alpha; tumour necrosis factor alpha; human whole blood; human blood mononuclear cell culture;
D O I：
10.1016/S0147-9571(96)00040-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The poxvirus preparation CONPIND initiated the production of the two major inflammatory mediators interleukin-1 alpha (IL-1 alpha) and tumour necrosis factor-alpha (TNF-alpha) in whole blood and in blood mononuclear cell cultures of man at 37 degrees C within 12-48 h. The release of the cytokines followed a dose-efficacy curve. High levels of IL1-alpha (up to 810 pg/ml) and TNF-alpha (up to 533 pg/ml) were determined by sandwich enzyme-linked immunosorbent assay.
引用
收藏
页码：139 / 145
页数：7
相关论文
共 50 条
  • [1] IL-1 alpha and TNF-alpha are the main mediators of acantholysis in pemphigus
    Claudio, F
    Paola, T
    Saman, MP
    Giulia, C
    Paolo, A
    Pierluigi, A
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1997, 109 (03) : 406 - 406
  • [2] IL-1, IL-6, and TNF-alpha release is downregulated in whole blood from septic patients
    Kremer, JP
    Jarrar, D
    Steckholzer, U
    Ertel, W
    MOLECULAR BIOLOGY OF HEMATOPOIESIS 5, 1996, : 637 - 644
  • [3] INTERLEUKIN-1-BETA (IL-1-BETA), IL-1 RECEPTOR ANTAGONIST, AND TNF-ALPHA PRODUCTION IN WHOLE-BLOOD
    NERAD, JL
    GRIFFITHS, JK
    VANDERMEER, JWM
    ENDRES, S
    POUTSIAKA, DD
    KEUSCH, GT
    BENNISH, M
    SALAM, MA
    DINARELLO, CA
    CANNON, JG
    JOURNAL OF LEUKOCYTE BIOLOGY, 1992, 52 (06) : 687 - 692
  • [4] Effects of the dialysis membrane on TNF-alpha and IL-1 beta in peripheral blood mononuclear cells of hemodialysis patients.
    Kushihata, S
    Yorioka, N
    Oda, H
    Yamakido, M
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1997, 8 : A1312 - A1312
  • [5] Effect of Steriods on TNF-Alpha Expression in Whole Blood Cell Cultures of Individuals with Human Immunodefficiency Virus Infection
    Raju, R.
    Sagili, K. D.
    Reddy, P. P.
    Suneetha, S.
    Suneetha, L. M.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2008, 12 : E244 - E244
  • [6] IL-1 alpha and TNF-alpha upregulate IL-6 production by healthy human gingival fibroblasts.
    Kent, L
    Rahemtulla, F
    Michalek, SM
    JOURNAL OF DENTAL RESEARCH, 1997, 76 : 2679 - 2679
  • [7] HUMAN WHOLE-BLOOD INTERLEUKIN-1-BETA PRODUCTION - KINETICS, CELL SOURCE, AND COMPARISON WITH TNF-ALPHA
    ALLEN, JN
    HERZYK, DJ
    ALLEN, ED
    WEWERS, MD
    JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1992, 119 (05): : 538 - 546
  • [8] PRODUCTION OF TNF-ALPHA AND IL-1 IN ACTIVE BEHCETS-DISEASE
    HAMZAOUI, K
    HAMZA, M
    AYED, K
    JOURNAL OF RHEUMATOLOGY, 1990, 17 (10) : 1428 - 1429
  • [9] Roles of TNF-alpha and IL-1 in mediating the inflammatory responses to ricin in macrophages
    Korcheva, VB
    Wong, J
    Magun, B
    FASEB JOURNAL, 2006, 20 (04): : A649 - A650
  • [10] Cytokine production (IL-6 and TNF alpha) in whole blood cell cultures of patients with systemic lupus erythematosus
    Swaak, AJG
    vandenBrink, HG
    Aarden, LA
    SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 1996, 25 (04) : 233 - 238
12345